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Substance Name: Canrenone [USAN:INN]
RN: 976-71-6
UNII: 78O20X9J0U
InChIKey: UJVLDDZCTMKXJK-WNHSNXHDSA-N

Note

  • A synthetic pregnadiene compound with anti-aldosterone activity.

Molecular Formula

  • C22-H28-O3

Molecular Weight

  • 340.4602
 

Classification Codes

  • Aldosterone Antagonist
  • Diuretics
  • Diuretics, Potassium Sparing
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Mineralocorticoid Receptor Antagonists
  • Natriuretic Agents
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Names and Synonyms

Name of Substance

  • Canrenone
  • Canrenone [USAN:INN]

MeSH Heading

  • Canrenone

Synonyms

  • 11614 R. P.
  • 11614 R.P
  • 17-Hydroxy-3-oxo-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactone
  • 17alpha-(2-Carboxyethyl)-17beta-hydroxyandrosta-4,6-dien-3-one lactone
  • 5-17-11-00476 (Beilstein Handbook Reference)
  • Aldadiene
  • Aldadiene (VAN)
  • BRN 0046602
  • Canrenona
  • Canrenona [INN-Spanish]
  • Canrenone
  • Canrenonum
  • Canrenonum [INN-Latin]
  • EC 213-554-5
  • EINECS 213-554-5
  • Luvion
  • NSC 261713
  • Phanurane
  • RP 11641
  • SC 9376
  • SC-9376
  • Spirolactone SC 14266
  • UNII-78O20X9J0U

Systematic Names

  • 17alpha-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (8CI)
  • Canrenone
  • Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, gamma-lactone (17alpha)-

Registry Numbers

CAS Registry Number

  • 976-71-6

FDA UNII

  • 78O20X9J0U

System Generated Number

  • 0000976716

Structure Descriptors

InChI

1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1

InChIKey

UJVLDDZCTMKXJK-WNHSNXHDSA-N

Smiles

C[C@]12CCC(=O)C=C1C=C[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]45CCC(=O)O5)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral > 5gm/kg (5000mg/kg)   Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 36, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 150 deg C   EXP
log P (octanol-water) 2.68 (none)   EXP
Water Solubility 36.4 mg/L 25 EST
Vapor Pressure 6.85E-09 mm Hg 25 EST
Henry's Law Constant 9.63E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.91E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.