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Substance Name: Vindolinine dihydrochloride
RN: 976-78-3
InChIKey: AZCNDDPKXMVQEE-RVNMPQILSA-N

Note

  • Alkaloid isolated from Catharanthus trichophyllus roots & Vinca rosea (Catharanthus); tested against experimental neoplasms.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H24-N2-O2.2Cl-H

Molecular Weight

  • 409.3544
 
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Names and Synonyms

Results Name

  • Vindolinine dihydrochloride

Synonyms

  • Vindolinine dihydrochloride
  • Vindolinine HCl

Systematic Names

  • 2,20-Cycloaspidospermidine-3-carboxylic acid, 6,7-didehydro-, methyl ester, dihydrochloride, (2-alpha,3-beta,5-alpha,12-beta,19-alpha,20R)-
  • Vindolinine, dihydrochloride (8CI)

Registry Numbers

CAS Registry Number

  • 976-78-3

System Generated Number

  • 0000976783

Molecular Formulas

Molecular Formula

  • C21-H24-N2-O2.2Cl-H

Molecular Formula Fragments

  • C21-H24-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H24N2O2.2ClH/c1-13-19-8-5-10-23-11-9-20(18(19)23)14-6-3-4-7-16(14)22-21(13,20)15(12-19)17(24)25-2;;/h3-8,13,15,18,22H,9-12H2,1-2H3;2*1H/t13-,15+,18+,19+,20-,21-;;/m1../s1

InChIKey

AZCNDDPKXMVQEE-RVNMPQILSA-N

Smiles

C[C@@H]1[C@]23C[C@H]([C@@]14[C@@]5([C@H]2N(CC5)CC=C3)c6ccccc6N4)C(=O)OC.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) "Catharanthus Alkaloids," Taylor, W.I., and N.R. Farnsworth, eds., New York, Marcel Dekker, 1975Vol. -, Pg. 73, 1975.