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Substance Name: Pyrazinamide [USP:INN:BAN:JAN]
RN: 98-96-4
UNII: 2KNI5N06TI
InChIKey: IPEHBUMCGVEMRF-UHFFFAOYSA-N
Note
- A pyrazine that is used therapeutically as an antitubercular agent.
Molecular Formula
- C5-H5-N3-O
Molecular Weight
- 123.1145
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Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial (Tuberculostatic)
- Antitubercular Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Tumor Data
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Names and Synonyms
Name of Substance
- Pyrazinamide
- Pyrazinamide [USP:INN:BAN:JAN]
MeSH Heading
- Pyrazinamide
Synonyms
- 2-Carbamylpyrazine
- 2-Pyrazinecarboxamide
- 5-25-04-00178 (Beilstein Handbook Reference)
- Aldinamid
- Aldinamide
- BRN 0112306
- CCRIS 545
- D-50
- D-50 (VAN)
- DRG 0124
- EINECS 202-717-6
- Eprazin
- Farmizina
- HSDB 3576
- Isopas
- MK 56
- NCI-C01785
- Novamid
- NSC 14911
- Pirazinamid
- Pirazinamida
- Pirazinamida [INN-Spanish]
- Pirazinamide
- Pirazinamide [DCIT]
- Pyrafat
- Pyrazinamide
- Pyrazinamidum
- Pyrazinamidum [INN-Latin]
- Pyrazine carboxamide
- Pyrazine carboxylamide
- Pyrazineamide
- Pyrazinecarboxylic acid amide
- Pyrazinoic acid amide
- PZA
- Rifafour
- Rifafour e-200
- Tebrazid
- Tisamid
- UNII-2KNI5N06TI
- Unipyranamide
- Zinamide
Systematic Names
- 2-Pyrazinecarboxamide
- Pyrazinamide
- Pyrazinecarboxamide
Superlist Name
- Pyrazinamide
Mixture Name
- Rifater
Registry Numbers
CAS Registry Number
- 98-96-4
FDA UNII
- 2KNI5N06TI
System Generated Number
- 0000098964
Structure Descriptors
InChI
1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)InChIKey
IPEHBUMCGVEMRF-UHFFFAOYSA-NSmiles
c1cnc(cn1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 1680mg/kg (1680mg/kg) | Chemotherapia. Vol. 5, Pg. 39, 1962. | |
mouse | LD50 | subcutaneous | 2973mg/kg (2973mg/kg) | Drugs in Japan Vol. -, Pg. 1038, 1995. | |
mouse | LDLo | oral | 3gm/kg (3000mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA | American Review of Tuberculosis. Vol. 70, Pg. 423, 1954. |
rat | LDLo | oral | 3gm/kg (3000mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA | American Review of Tuberculosis. Vol. 70, Pg. 423, 1954. |
women | TDLo | oral | 10mg/kg (10mg/kg) | VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION | JAMA, Journal of the American Medical Association. Vol. 127, Pg. 1356, 1997. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 192 | deg C | EXP | |
pKa Dissociation Constant | -0.5 | (none) | EXP | |
log P (octanol-water) | -0.6 | (none) | EXP | |
Water Solubility | 1.50E+04 | mg/L | 25 | EXP |
Vapor Pressure | 2.44E-04 | mm Hg | 25 | EST |
Henry's Law Constant | 1.20E-12 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.21E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.