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Substance Name: Fosinopril [INN:BAN]
RN: 98048-97-6
UNII: R43D2573WO
InChIKey: BIDNLKIUORFRQP-XYGFDPSESA-N

Note

  • A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.

Molecular Formula

  • C30-H46-N-O7-P

Molecular Weight

  • 563.6674
 

Classification Codes

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Enzyme Inhibitors
  • Protease Inhibitors

Names and Synonyms

Name of Substance

  • Fosinopril
  • Fosinopril [INN:BAN]

MeSH Heading

  • Fosinopril

Synonyms

  • Fosinopril
  • UNII-R43D2573WO

Systematic Names

  • L-Proline, 4-cyclohexyl-1-(((2-methyl-1-(1-oxopropoxy)propoxy)(4-phenylbutyl)phosphinyl)acetyl)-, (1(S*(R*)),2alpha,4beta)-
  • L-Proline, 4-cyclohexyl-1-(((2-methyl-1-(1-oxopropoxy)propoxy)(4-phenylbutyl)phosphinyl)acetyl)-, (2alpha,4beta)-

Registry Numbers

CAS Registry Number

  • 98048-97-6

FDA UNII

  • R43D2573WO

System Generated Number

  • 0098048976

Structure Descriptors

InChI

1S/C30H46NO7P/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35)/t25-,26+,30+,39-/m1/s1

InChIKey

BIDNLKIUORFRQP-XYGFDPSESA-N

Smiles

CCC(=O)O[C@@H](O[P@](=O)(CCCCc1ccccc1)CC(=O)N2C[C@@H](C[C@H]2C(=O)O)C3CCCCC3)C(C)C

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 6.610 (none)   EST
Atmospheric OH Rate Constant 1.29E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.