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Substance Name: Lomefloxacin [USAN:INN:BAN]
RN: 98079-51-7
UNII: L6BR2WJD8V
InChIKey: ZEKZLJVOYLTDKK-UHFFFAOYSA-N

Molecular Formula

  • C17-H19-F2-N3-O3

Molecular Weight

  • 351.351
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Mutation Data
  • Skin / Eye Irritant
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors

Names and Synonyms

Name of Substance

  • Lomefloxacin
  • Lomefloxacin [USAN:INN:BAN]

Synonyms

  • (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • BRN 4210041
  • CCRIS 6305
  • DM 10 (bactericide)
  • DM-10
  • Lomefloxacin
  • Lomefloxacine
  • Lomefloxacine [French]
  • Lomefloxacino
  • Lomefloxacino [Spanish]
  • Lomefloxacinum
  • Lomefloxacinum [Latin]
  • SC 47111A
  • SC-47111A
  • UNII-L6BR2WJD8V

Systematic Names

  • 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-
  • 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, (+-)-
  • Lomefloxacin

Registry Numbers

CAS Registry Number

  • 98079-51-7

FDA UNII

  • L6BR2WJD8V

Related Registry Number

  • 98079-52-8 (hydrochloride)

System Generated Number

  • 0098079517

Structure Descriptors

InChI

1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)

InChIKey

ZEKZLJVOYLTDKK-UHFFFAOYSA-N

Smiles

N1[C@@H](C)CN(CC1)c1c(F)cc2c(c(cn(c2c1F)CC)C(O)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 698mg/kg (698mg/kg)   Ensho. Japanese Journal of Inflammation. Vol. 11, Pg. 343, 1991.
mouse LD50 intravenous 246mg/kg (246mg/kg)   United States Patent Document. Vol. #4528287,
mouse LD50 oral > 4gm/kg (4000mg/kg)   United States Patent Document. Vol. #4528287,
rat LD50 oral 3800mg/kg (3800mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 83, 1990.
women TDLo oral 24mg/kg/3D-I (24mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
American Journal of Psychiatry. Vol. 152, Pg. 954, 1995.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 239-240.5 deg C   EXP
log P (octanol-water) -0.3 (none)   EXP
Water Solubility 2.72E+04 mg/L 25 EST
Vapor Pressure 4.75E-13 mm Hg 25 EST
Henry's Law Constant 1.35E-18 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.34E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.