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Substance Name: Lomefloxacin hydrochloride [USAN:JAN]
RN: 98079-52-8
UNII: 9VC7S3ZXXB
InChIKey: KXEBLAPZMOQCKO-UHFFFAOYSA-N

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C17-H19-F2-N3-O3.Cl-H

Molecular Weight

  • 387.812
 
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Names and Synonyms

Name of Substance

  • Lomefloxacin hydrochloride [USAN:JAN]

Synonyms

  • (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride
  • Bareon
  • CCRIS 2581
  • Lomefloxacin HCl
  • Lomefloxacin hydrochloride
  • Maxaquin
  • Mazaquin
  • NY 198
  • NY-198
  • SC-47111
  • UNII-9VC7S3ZXXB

Systematic Names

  • 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride
  • 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride, (+-)-
  • NY-198

Registry Numbers

CAS Registry Number

  • 98079-52-8

FDA UNII

  • 9VC7S3ZXXB

Related Registry Number

  • 98079-51-7 (Parent)

System Generated Number

  • 0098079528

Molecular Formulas

Molecular Formula

  • C17-H19-F2-N3-O3.Cl-H

Molecular Formula Fragments

  • C17-H19-F2-N3-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H

InChIKey

KXEBLAPZMOQCKO-UHFFFAOYSA-N

Smiles

N1[C@@H](C)CN(CC1)c1c(F)cc2c(c(cn(c2c1F)CC)C(O)=O)=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 50mg/kg (50mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1288, 1990.
mouse LD50 intravenous 253mg/kg (253mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Chemotherapy Vol. 36(Suppl,
mouse LD50 oral 1608mg/kg (1608mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Chemotherapy Vol. 36(Suppl,
mouse LD50 subcutaneous 995mg/kg (995mg/kg)   Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. Vol. 19, Pg. 154, 1994.
rat LD50 intravenous 328mg/kg (328mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Chemotherapy Vol. 36(Suppl,
rat LD50 oral 1556mg/kg (1556mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Chemotherapy Vol. 36(Suppl,
rat LD50 subcutaneous 1637mg/kg (1637mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Chemotherapy Vol. 36(Suppl,