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Substance Name: Clopenthixol [USAN:INN:BAN]
RN: 982-24-1
UNII: 0A432D932A
InChIKey: WFPIAZLQTJBIFN-BLLMUTORSA-N

Note

  • A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Molecular Formula

  • C22-H25-Cl-N2-O-S

Molecular Weight

  • 400.9715
 

Classification Codes

  • Antipsychotic
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Tranquilizing Agents
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Names and Synonyms

Name of Substance

  • Clopenthixol
  • Clopenthixol [USAN:INN:BAN]

MeSH Heading

  • Clopenthixol

Synonyms

  • 1-Piperazineethanol, 4-(3-(2-chloro-9H-thioxanthen-9-ylidene)propyl)-
  • 1-Piperazineethanol, 4-(3-(2-chlorothioxanthen-9-ylidene)propyl)-
  • 4-(3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl)-1-piperazineethanol
  • 4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-1-piperazineethanol
  • Chlorpenthixol
  • Clopenthixol
  • Clopenthixolum
  • Clopenthixolum [INN-Latin]
  • Clopentixol
  • Clopentixol [INN-Spanish]
  • EINECS 213-566-0
  • Sordinol
  • UNII-0A432D932A

Systematic Names

  • 1-Piperazineethanol, 4-(3-(2-chloro-9H-thioxanthen-9-ylidene)propyl)-
  • Clopenthixol

Registry Numbers

CAS Registry Number

  • 982-24-1

FDA UNII

  • 0A432D932A

System Generated Number

  • 0000982241

Structure Descriptors

InChI

1S/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2/b18-5+

InChIKey

WFPIAZLQTJBIFN-BLLMUTORSA-N

Smiles

c1ccc2c(c1)/C(=C\CCN3CCN(CC3)CCO)/c4cc(ccc4S2)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 226mg/kg (226mg/kg)   European Patent Application. Vol. #0002902,

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.18 (none)   EXP
Water Solubility 0.643 mg/L 25 EST
Vapor Pressure 2.94E-13 mm Hg 25 EST
Henry's Law Constant 3.53E-17 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.04E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.