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Substance Name: Chloramphenicol sodium succinate [USP:BAN:JAN]
RN: 982-57-0
UNII: 872109HX6B
InChIKey: RPLOPBHEZLFENN-HTMVYDOJSA-M

Note

  • Inactive precursor (PRODRUGS) of chloramphenicol; used for parenteral administration of chloramphenicol.

Molecular Formulas

  • C15-H15-Cl2-N2-Na-O8
  • C15-H15-Cl2-N2-O8.Na
  • C15-H16-Cl2-N2-O8.Na

Molecular Weight

  • 445.1855
 

Classification Codes

  • Antibacterial
  • Antirickettsial
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Chloramphenicol sodium succinate [USP:BAN:JAN]

MeSH Heading

  • Chloramphenicol

Synonyms

  • Butanedioic acid, mono(2-((2,2-dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propyl) ester, monosodium salt, (R-(R*,R*))-
  • CCRIS 6204
  • Chloramphenicol monosuccinate sodium salt
  • Chloramphenicol sodium monosuccinate
  • Chloramphenicol sodium succinate
  • Chloramphenicol sodium succinate, d-
  • Chloramphenicol succinate sodium
  • Chloramphenicol-sukzinat-natrium
  • Chloramphenicol-sukzinat-natrium [German]
  • Chloromycetin
  • D-threo-(-)-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)acetamide alpha-(sodium succinate)
  • EINECS 213-568-1
  • Mychel-S
  • Protophenicol
  • Sodium chloramphenicol succinate
  • UNII-872109HX6B

Systematic Names

  • Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)-, alpha-ester with sodium succinate
  • Butanedioic acid, mono((2R,3R)-2-((dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propyl) ester, monosodium salt
  • Butanedioic acid, mono(2-((2,2-dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propyl) ester, monosodium salt, (R-(R(sup *),R(sup *)))(-)
  • Chloramphenicol sodium succinate

Registry Numbers

CAS Registry Number

  • 982-57-0

FDA UNII

  • 872109HX6B

Related Registry Number

  • 3544-94-3 (Parent)

System Generated Number

  • 0000982570

Molecular Formulas

Molecular Formulas

  • C15-H15-Cl2-N2-Na-O8
  • C15-H15-Cl2-N2-O8.Na
  • C15-H16-Cl2-N2-O8.Na

Molecular Formula Fragments

  • C15-H15-Cl2-N2-O8
  • C15-H16-Cl2-N2-O8
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C15H16Cl2N2O8.Na/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);/q;+1/p-1/t10-,13-;/m1./s1

InChIKey

RPLOPBHEZLFENN-HTMVYDOJSA-M

Smiles

c1cc(ccc1[C@H]([C@@H](COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
infant LDLo intravenous 135mg/kg/3D-I (135mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: IRRITABILITY

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Pediatrics. Vol. 103, Pg. 485, 1983.
mouse LD50 intravenous 1530mg/kg (1530mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.
rat LD50 intraperitoneal 1400mg/kg (1400mg/kg)   Drugs in Japan Vol. 6, Pg. 248, 1982.
rat LD50 intravenous 1500mg/kg (1500mg/kg)   Drugs in Japan Vol. 6, Pg. 248, 1982.