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Substance Name: Reboxetine [INN:BAN]
RN: 71620-89-8
UNII: 947S0YZ36I
InChIKey: CBQGYUDMJHNJBX-RTBURBONSA-N

Note

  • Potent antidepressant; also prevents clonidine-induced hypothermia in mice.

Molecular Formula

  • C19-H23-N-O3

Molecular Weight

  • 313.3947
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents
  • Central Nervous System Agents
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Psychotropic Drugs
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Names and Synonyms

Name of Substance

  • Reboxetine
  • Reboxetine [INN:BAN]

Synonyms

  • HSDB 7701
  • Reboxetine
  • UNII-947S0YZ36I
  • Vestra

Systematic Name

  • Morpholine, 2-((R)-(2-ethoxyphenoxy)phenylmethyl)-, (2R)-rel-

Registry Numbers

CAS Registry Number

  • 71620-89-8

FDA UNII

  • 947S0YZ36I

Other Registry Numbers

  • 71621-36-8
  • 98769-81-4
  • 98769-83-6

System Generated Number

  • 0071620898

Structure Descriptors

InChI

1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3/t18-,19-/m1/s1

InChIKey

CBQGYUDMJHNJBX-RTBURBONSA-N

Smiles

C1CNC[C@@H](O1)[C@@H](c1ccccc1)Oc1ccccc1OCC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 457ug/kg/8D-I (0.457mg/kg)   New England Journal of Medicine. Vol. 342, Pg. 215, 2000.
man TDLo oral 457ug/kg/8D-I (0.457mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING New England Journal of Medicine. Vol. 342, Pg. 215, 2000.