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Substance Name: Methylparaben [USAN:NF]
RN: 99-76-3
UNII: A2I8C7HI9T
InChIKey: LXCFILQKKLGQFO-UHFFFAOYSA-N
Note
- Used as a preservative in cosmetics but potentiates UV-induced damage of skin.
Molecular Formula
- C8-H8-O3
Molecular Weight
- 152.1482
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Drug / Therapeutic Agent
- Mutation Data
- Pharmaceutic Aid (Antifungal Agent)
- Pharmaceutic Aids
- Preservatives, Pharmaceutical
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Links to Resources
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Names and Synonyms
Name of Substance
- 4-Hydroxybenzoic acid, methyl ester
- Benzoic acid, 4-hydroxy-, methyl ester
- Methyl 4-hydroxybenzoate
- Methyl p-hydroxybenzoate
- Methyl parahydroxybenzoate
- Methylparaben
- Methylparaben [USAN:NF]
Synonyms
- 4-(Methoxycarbonyl)phenol
- 4-10-00-00360 (Beilstein Handbook Reference)
- 4-Hydroxybenzoic acid methyl ester
- Abiol
- AI3-01336
- Aseptoform
- Benzoic acid, 4-hydroxy-, methyl ester
- Benzoic acid, p-hydroxy-, methyl ester
- BRN 0509801
- Caswell No. 573PP
- CCRIS 3946
- EC 202-785-7
- EINECS 202-785-7
- EPA Pesticide Chemical Code 061201
- FEMA No. 2710
- FEMA Number 2710
- HSDB 1184
- Maseptol
- Metaben
- Methaben
- Methyl 4-hydroxybenzoate
- Methyl butex
- Methyl chemosept
- Methyl ester of p-hydroxybenzoic acid
- Methyl p-hydroxybenzoate
- Methyl p-oxybenzoate
- Methyl paraben
- Methyl parahydroxybenzoate
- Methyl parasept
- Methylben
- Methylester kyseliny p-hydroxybenzoove
- Methylester kyseliny p-hydroxybenzoove [Czech]
- Methylparaben
- Metoxyde
- Moldex
- Nipagin
- Nipagin M
- NSC 3827
- p-Carbomethoxyphenol
- p-Hydroxybenzoic acid methyl ester
- p-Methoxycarbonylphenol
- p-Oxybenzoesauremethylester
- p-Oxybenzoesauremethylester [German]
- Paridol
- Preserval
- Preserval M
- Septos
- Solbrol
- Solbrol M
- Tegosept M
- UNII-A2I8C7HI9T
Systematic Names
- Benzoic acid, 4-hydroxy-, methyl ester
- Benzoic acid, p-hydroxy-, methyl ester
- Methyl 4-hydroxybenzoate
- Methyl-p-hydroxybenzoate
Superlist Names
- Benzoic acid, p-hydroxy-, methyl ester
- Methyl 4-hydroxybenzoate
- Methyl p-hydroxybenzoate
- Methylparaben
Registry Numbers
CAS Registry Number
- 99-76-3
FDA UNII
- A2I8C7HI9T
Other Registry Numbers
- 1000398-37-7
- 156291-94-0
- 58339-84-7
Related Registry Number
- 5026-62-0 (hydrochloride salt)
System Generated Number
- 0000099763
Structure Descriptors
InChI
InChI=1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3InChIKey
LXCFILQKKLGQFO-UHFFFAOYSA-NSmiles
COC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 3gm/kg (3000mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. | |
mouse | LD50 | intraperitoneal | 960mg/kg (960mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956. |
mouse | LD50 | oral | > 8gm/kg (8000mg/kg) | BEHAVIORAL: ATAXIA PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956. |
mouse | LD50 | subcutaneous | 1200mg/kg (1200mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 135, 1960. | |
rabbit | LD50 | oral | 6gm/kg (6000mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. | |
rat | LD50 | subcutaneous | > 500mg/kg (500mg/kg) | Clinical Toxicology. Vol. 4(2), Pg. 185, 1971. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 131 | deg C | EXP | |
Boiling Point | 275 dec | deg C | EXP | |
log P (octanol-water) | 1.96 | (none) | EXP | |
Water Solubility | 2500 | mg/L | 25 | EXP |
Vapor Pressure | 2.37E-04 | mm Hg | 25 | EST |
Henry's Law Constant | 2.16E-08 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.11E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.