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Substance Name: Proglumide sodium
RN: 99247-33-3
InChIKey: UFMWGCINVOIJSO-UHFFFAOYSA-M

Note

  • A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formulas

  • C18-H25-N2-O4.Na
  • C18-H26-N2-O4.Na

Molecular Weight

  • 356.3955
 
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Names and Synonyms

Name of Substance

  • Proglumide sodium

Synonyms

  • dl-4-Benzamido-N,N-dipropylglutaramic acid sodium salt
  • Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, monosodium salt, (+-)-
  • Proglumide sodium

Systematic Names

  • Glutaramic acid, 4-benzamido-N,N-dipropyl-, sodium salt, dl-
  • Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, monosodium salt, (+-)-

Registry Numbers

CAS Registry Number

  • 99247-33-3

System Generated Number

  • 0099247333

Molecular Formulas

Molecular Formulas

  • C18-H25-N2-O4.Na
  • C18-H26-N2-O4.Na

Molecular Formula Fragments

  • C18-H25-N2-O4
  • C18-H26-N2-O4
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C18H26N2O4.Na/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14;/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22);/q;+1/p-1

InChIKey

UFMWGCINVOIJSO-UHFFFAOYSA-M

Smiles

CCCN(CCC)C(=O)C(CCC(=O)[O-])NC(=O)c1ccccc1.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2811mg/kg (2811mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 203, 1971.
mouse LD50 intravenous 2968mg/kg (2968mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: HEMATURIA
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 203, 1971.
mouse LD50 oral 8900mg/kg (8900mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: HEMATURIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 203, 1971.
mouse LD50 subcutaneous 5886mg/kg (5886mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: HEMATURIA
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 203, 1971.
rat LD50 intraperitoneal 2360mg/kg (2360mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 203, 1971.
rat LD50 oral 8200mg/kg (8200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: HEMATURIA
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 203, 1971.
rat LD50 subcutaneous 6110mg/kg (6110mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 203, 1971.