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Substance Name: Levodropropizine [INN:BAN]
RN: 99291-25-5
UNII: 3O31P6T4G3
InChIKey: PTVWPYVOOKLBCG-ZDUSSCGKSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C13-H20-N2-O2

Molecular Weight

  • 236.313
 
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Names and Synonyms

Name of Substance

  • Levodropropizine [INN:BAN]

Synonyms

  • (-)-Dropropizine
  • Danka
  • DF 526
  • Levdropropizine
  • Levodropropizina
  • Levodropropizina [INN-Spanish]
  • Levodropropizine
  • Levodropropizinum
  • Levodropropizinum [INN-Latin]
  • Levotuss
  • S(-)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
  • UNII-3O31P6T4G3

Systematic Names

  • (-)-(S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
  • 1,2-Propanediol, 3-(4-phenylpiperazin-1-yl)-, S(-)-

Registry Numbers

CAS Registry Number

  • 99291-25-5

FDA UNII

  • 3O31P6T4G3

System Generated Number

  • 0099291255

Structure Descriptors

InChI

1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1

InChIKey

PTVWPYVOOKLBCG-ZDUSSCGKSA-N

Smiles

C1N(CCN(C1)c1ccccc1)C[C@@H](CO)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 2493mg/kg (2493mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1150, 1988.
mouse LD50 intraperitoneal 408mg/kg (408mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1150, 1988.
mouse LD50 oral 1281mg/kg (1281mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1150, 1988.
rat LD50 intraperitoneal 401mg/kg (401mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1150, 1988.
rat LD50 oral 887mg/kg (887mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1150, 1988.