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Substance Name: Ondansetron [USP:INN:BAN]
RN: 99614-02-5
UNII: 4AF302ESOS
InChIKey: FELGMEQIXOGIFQ-UHFFFAOYSA-N

Note

  • A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Molecular Formula

  • C18-H19-N3-O

Molecular Weight

  • 293.3681
 

Classification Codes

  • Anti-Anxiety Agents
  • Antiemetics
  • Antipruritics
  • Antipsychotic Agents
  • Autonomic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dermatologic Agents
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Human Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Serotonin Agents
  • Serotonin Antagonists
  • Tranquilizing Agents

Names and Synonyms

Name of Substance

  • Ondansetron
  • Ondansetron [USP:INN:BAN]

MeSH Heading

  • Ondansetron

Synonyms

  • (RS)-1,2,3,9-Tetrahydro-9-methyl-3-(2-methylimidazol-1-ylmethyl)carbazol-4-one
  • 1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one
  • BRN 3622981
  • GR 38032
  • GR 38032X
  • HSDB 8304
  • Odansetron [common misspelling of ondansetron]
  • Ondansetron
  • Ondansetron Injection
  • UNII-4AF302ESOS
  • Zofran
  • Zofran ODT
  • Zophren
  • Zudan
  • Zuplenz

Systematic Name

  • 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-

Registry Numbers

CAS Registry Number

  • 99614-02-5

FDA UNII

  • 4AF302ESOS

Other Registry Numbers

  • 108303-49-7
  • 116002-70-1

Related Registry Numbers

  • 103639-04-9 (mono-hydrochloride dihydrate)
  • 99614-01-4 (mono-hydrochloride)

System Generated Number

  • 0099614025

Structure Descriptors

InChI

1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3

InChIKey

FELGMEQIXOGIFQ-UHFFFAOYSA-N

Smiles

Cc1nccn1CC2CCc3c(c4ccccc4n3C)C2=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 10mg/kg (10mg/kg)   Seminars in Oncology. Vol. 19(Suppl,
man TDLo intravenous 229ug/kg/I (0.229mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" Lancet. Vol. 344, Pg. 190, 1994.
mouse LD intraperitoneal > 5mg/kg (5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 46, Pg. 401, 1996.
mouse LD oral > 10mg/kg (10mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 46, Pg. 401, 1996.
mouse LDLo intravenous 2500ug/kg (2.5mg/kg)   Seminars in Oncology. Vol. 19(Suppl,
rat LDLo intravenous 20mg/kg (20mg/kg)   Seminars in Oncology. Vol. 19(Suppl,