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Substance Name: Nasaruplase [INN]
RN: 99821-44-0

Note

  • A native single-chain urokinase-type plasminogen activator; a proenzyme converted only at the thrombus surface.

Molecular Formula

  • C2031-H3121-N585-O601-S31
 

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product
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Names and Synonyms

Name of Substance

  • Nasaruplase
  • Nasaruplase [INN]

Synonyms

  • Nasaruplase
  • Prourokinase (enzyme-activating) (human clone pA3/pD2/pF1 protein moiety), glycosylated

Systematic Names

  • Kinase (enzyme-activating), preprouro- (human clone pA3/pD2/pF1 protein moiety)
  • Nasaruplase
  • Prourokinase (enzyme-activating) (human clone pA3pD2pF1 protein moiety)

Registry Numbers

CAS Registry Number

  • 99821-44-0

System Generated Number

  • 0099821440

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 intravenous > 55ku/kg (55000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
monkey LD50 unreported > 55ku/kg (55000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
mouse LD50 intravenous > 55ku/kg (55000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
mouse LD50 oral > 55ku/kg (55000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
mouse LD50 subcutaneous > 55ku/kg (55000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 intravenous > 55ku/kg (55000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 oral > 55ku/kg (55000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 subcutaneous > 55ku/kg (55000iu/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.