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Substance Name: Hexamethyldisilazane
RN: 999-97-3
UNII: H36C68P1BH
InChIKey: FFUAGWLWBBFQJT-UHFFFAOYSA-N

Classification Codes

  • Fixatives
  • Skin / Eye Irritant
  • Tumor Data

Molecular Formula

  • C6-H19-N-Si2

Molecular Weight

  • 161.395
 
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Names and Synonyms

Name of Substance

  • Hexamethyldisilazane
  • Hexamethylsilazane

Synonyms

  • 1,1,1,3,3,3-Hexamethyldisilazane
  • 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine
  • AI3-51467
  • Bis(trimethylsilyl)amine
  • CCRIS 2456
  • EC 213-668-5
  • EINECS 213-668-5
  • Hexamethyldisilazane
  • Hexamethylsilazane
  • HMDS
  • HSDB 7226
  • NSC 93895
  • OAP
  • SZ 6079
  • Tri-Sil
  • TSL 8802
  • UNII-H36C68P1BH

Systematic Names

  • 1,1,1,3,3,3-Hexamethyldisilazane
  • 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine
  • Disilazane, 1,1,1,3,3,3-hexamethyl-
  • Hexamethyldisilazane
  • Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-

Superlist Name

  • Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-

Registry Numbers

CAS Registry Number

  • 999-97-3

FDA UNII

  • H36C68P1BH

Other Registry Numbers

  • 103737-28-6
  • 116638-29-0
  • 127290-38-4
  • 18186-75-9
  • 761458-30-4

Related Registry Numbers

  • 1070-89-9 (hydrochloride salt)
  • 1070-89-9 (Na salt)
  • 4039-32-1 (lithium salt)

System Generated Number

  • 0000999973

Structure Descriptors

InChI

1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

InChIKey

FFUAGWLWBBFQJT-UHFFFAOYSA-N

Smiles

[Si](N[Si](C)(C)C)(C)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 skin 1mL/kg (1mL/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: TREMOR

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 National Technical Information Service. Vol. OTS0537734,
mouse LC50 inhalation 12gm/m3/2H (12000mg/m3) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: PULSE RATE 		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(5), Pg. 52, 1986.
mouse LD50 intravenous > 100mg/kg (100mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
mouse LD50 oral 850mg/kg (850mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: PULSE RATE

BEHAVIORAL: GENERAL ANESTHETIC		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(5), Pg. 52, 1986.
mouse LDLo intraperitoneal 650mg/kg (650mg/kg) IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975Vol. 27MAY1975,
rabbit LD50 oral 1100mg/kg (1100mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: PULSE RATE

BEHAVIORAL: GENERAL ANESTHETIC		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(5), Pg. 52, 1986.
rabbit LD50 skin 710uL/kg (0.71mL/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 576, 1993.
rat LC50 inhalation 8700mg/m3/4H (8700mg/m3) CARDIAC: PULSE RATE

BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(5), Pg. 52, 1986.
rat LD50 intraperitoneal 800mg/kg (800mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: TREMOR		 National Technical Information Service. Vol. OTS0537734,
rat LD50 oral 850mg/kg (850mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: PULSE RATE

BEHAVIORAL: GENERAL ANESTHETIC		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(5), Pg. 52, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Boiling Point 125 deg C   EXP
log P (octanol-water) 2.620 (none)   EST
Water Solubility 392 mg/L 25 EST
Vapor Pressure 13.8 mm Hg 25 EXP
Henry's Law Constant 8.69E-05 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 8.98E-13 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.