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Substance Name: Glycerin [USP:JAN]
RN: 56-81-5
UNII: PDC6A3C0OX
InChIKey: PEDCQBHIVMGVHV-UHFFFAOYSA-N

Note

  • A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.

Molecular Formula

  • C3-H8-O3

Molecular Weight

  • 92.0932
 

Classification Codes

Classification Codes

  • Cryoprotective Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Pharmaceutic Aid (Humectant)
  • Pharmaceutic Aid (Solvent)
  • Protective Agents
  • Reproductive Effect
  • Skin / Eye Irritant
  • Solvents

Superlist Classification Codes

  • TWA (15 mg/m3 total dust; 5 mg/m3 respirable fraction)
  • TWA 10 mg/m3

Names and Synonyms

Name of Substance

  • 1,2,3-Propanetriol
  • Glycerin
  • Glycerin [USP:JAN]
  • Glycerine
  • Glycerol
  • Glycerol [INN]

MeSH Heading

  • Glycerol

Synonyms

  • 1,2,3-Propanetriol
  • 1,2,3-Trihydroxypropane
  • 4-01-00-02751 (Beilstein Handbook Reference)
  • 90 Technical glycerine
  • AI3-00091
  • BRN 0635685
  • Caswell No. 469
  • CCRIS 2295
  • Citifluor AF 2
  • Clyzerin, wasserfrei
  • Clyzerin, wasserfrei [German]
  • Dagralax
  • EC 200-289-5
  • EINECS 200-289-5
  • EPA Pesticide Chemical Code 063507
  • FEMA No. 2525
  • Glicerina
  • Glicerina [DCIT]
  • Glicerol
  • Glicerol [INN-Spanish]
  • Glycerin
  • Glycerin, anhydrous
  • Glycerin, synthetic
  • Glycerine
  • Glycerinum
  • Glyceritol
  • Glycerol
  • Glycerolum
  • Glycerolum [INN-Latin]
  • Glycyl alcohol
  • Glyrol
  • Glysanin
  • Grocolene
  • HSDB 492
  • IFP
  • Incorporation factor
  • MOON
  • NSC 9230
  • Ophthalgan
  • Optim
  • Osmoglyn
  • Propanetriol
  • Propanetriol (VAN)
  • Star
  • Synthetic glycerin
  • Synthetic glycerine
  • Trihydroxypropane
  • UNII-PDC6A3C0OX
  • Vitrosupos

Systematic Names

  • 1,2,3-Propanetriol
  • Glycerol

Superlist Names

  • 1,2,3-Propanetriol
  • Glycerin
  • Glycerin (mist)
  • Glycerin mist
  • Glycerine
  • Glycerine mist
  • Glycerol

Mixture Names

  • Artifical tears
  • Auralgan
  • Collyrium Fresh-Eye Drops
  • Neutracett
  • Soothe

Registry Numbers

CAS Registry Number

  • 56-81-5

FDA UNII

  • PDC6A3C0OX

Other Registry Numbers

  • 1400594-62-8
  • 1422250-43-8
  • 1629856-20-7
  • 29796-42-7
  • 30049-52-6
  • 37228-54-9
  • 75398-78-6
  • 78630-16-7
  • 8013-25-0

System Generated Number

  • 0000056815

Structure Descriptors

InChI

InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2

InChIKey

PEDCQBHIVMGVHV-UHFFFAOYSA-N

Smiles

OCC(O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 7750mg/kg (7750mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
human TDLo oral 1428mg/kg (1428mg/kg) BEHAVIORAL: HEADACHE

GASTROINTESTINAL: NAUSEA OR VOMITING		 "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 288, 1969.
mouse LD50 intraperitoneal 8700mg/kg (8700mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1579, 1978.
mouse LD50 intravenous 4250mg/kg (4250mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 583, 1950.
mouse LD50 oral 4090mg/kg (4090mg/kg)   Farmatsevtichnii Zhurnal Vol. (6), Pg. 56, 1977.
mouse LD50 subcutaneous 91mg/kg (91mg/kg)   Drugs in Japan Vol. 6, Pg. 215, 1982.
rabbit LD50 intravenous 53gm/kg (53000mg/kg)   Drugs in Japan Vol. 6, Pg. 215, 1982.
rabbit LD50 oral 27gm/kg (27000mg/kg)   Delaware State Medical Journal. Vol. 31, Pg. 276, 1959.
rabbit LD50 skin > 10gm/kg (10000mg/kg)   BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 9-4/1970,
rat LC50 inhalation > 570mg/m3/1H (570mg/m3)   BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 9-4/1970,
rat LD50 intraperitoneal 4420mg/kg (4420mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: TOXIC PSYCHOSIS

KIDNEY, URETER, AND BLADDER: OTHER CHANGES 		Research Communications in Chemical Pathology and Pharmacology. Vol. 56, Pg. 125, 1987.
rat LD50 intravenous 5566mg/kg (5566mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 oral 12600mg/kg (12600mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

LIVER: OTHER CHANGES

BEHAVIORAL: MUSCLE WEAKNESS		 Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 142, 1945.
rat LD50 subcutaneous 100mg/kg (100mg/kg)   Drugs in Japan Vol. 6, Pg. 215, 1982.
rat LDLo intramuscular 10mg/kg (10mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"		 Nephron. Vol. 20, Pg. 47, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 18.2 deg C   EXP
Boiling Point 290 deg C   EXP
pKa Dissociation Constant 14.4 (none)   EXP
log P (octanol-water) -1.76E+00 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EXP
Vapor Pressure 1.68E-04 mm Hg 25 EXP
Henry's Law Constant 1.73E-08 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.87E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.