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Substance Name: Niacinamide [USP]
RN: 98-92-0
UNII: 25X51I8RD4
InChIKey: DFPAKSUCGFBDDF-UHFFFAOYSA-N

Note

  • An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.

Molecular Formula

  • C6-H6-N2-O

Molecular Weight

  • 122.1264
 

Classification Codes

  • Antiviral (COVID-19)
  • Drug / Therapeutic Agent
  • Growth Substances
  • Micronutrients
  • Mutation Data
  • Vitamin (Enzyme Co-Factor)
  • Vitamin B Complex
  • Vitamins

Names and Synonyms

Name of Substance

  • 3-Pyridinecarboxamide
  • Niacinamide
  • Niacinamide [USP]
  • Nicotinamide
  • Nicotinamide [INN]

MeSH Heading

  • Niacinamide

Synonyms

  • 3-Carbamoylpyridine
  • 3-Pyridinecarboxamide
  • AI3-02906
  • Amid kyseliny nikotinove
  • Amid kyseliny nikotinove [Czech]
  • Aminicotin
  • Amixicotyn
  • Amnicotin
  • Austrovit PP
  • Benicot
  • beta-Pyridinecarboxamide
  • CCRIS 1901
  • Delonin amide
  • Dipegyl
  • EC 202-713-4
  • EINECS 202-713-4
  • Endobion
  • Hansamid
  • HSDB 1237
  • Inovitan PP
  • m-(Aminocarbonyl)pyridine
  • NAM
  • Nandervit-N
  • Niacevit
  • Niacinamide
  • Niamide
  • Niavit PP
  • Nicamina
  • Nicamindon
  • Nicasir
  • Nicobion
  • Nicofort
  • Nicogen
  • Nicomidol
  • Nicosan 2
  • Nicosylamide
  • Nicota
  • Nicotamide
  • Nicotilamide
  • Nicotililamido
  • Nicotinamida
  • Nicotinamida [INN-Spanish]
  • Nicotinamide
  • Nicotinamidum
  • Nicotinamidum [INN-Latin]
  • Nicotine acid amide
  • Nicotine amide
  • Nicotinic acid amide
  • Nicotinic amide
  • Nicotinsaureamid
  • Nicotinsaureamid [German]
  • Nicotol
  • Nicotylamide
  • Nicotylamidum
  • Nicovit
  • Nicovitina
  • Nicovitol
  • Nicozymin
  • Niko-Tamin
  • Nikotinamid
  • Nikotinsaeureamid
  • Nikotinsaeureamid [German]
  • Niocinamide
  • Niozymin
  • NSC 13128
  • Papulex
  • Pelmine
  • Pelonin amide
  • Pyridine, 3-carbamoyl-
  • Pyridine-3-carboxylic acid amide
  • Savacotyl
  • UNII-25X51I8RD4
  • VI-Nicotyl
  • Vitamin B
  • Vitamin B (VAN)
  • Vitamin B3

Systematic Names

  • 3-Pyridinecarboxamide
  • Nicotinamide

Superlist Names

  • 3-Pyridinecarboxylic acid amide
  • Niacinamide
  • Nicotinamide

Mixture Name

  • Mediatric

Registry Numbers

CAS Registry Number

  • 98-92-0

FDA UNII

  • 25X51I8RD4

Other Registry Numbers

  • 123574-63-0
  • 37321-14-5
  • 78731-47-2

System Generated Number

  • 0000098920

Structure Descriptors

InChI

InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChIKey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Smiles

NC(=O)c1cccnc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 2500mg/kg (2500mg/kg)   Pharmaceutical Chemistry Journal Vol. 20, Pg. 29, 1986.
mouse LD50 intraperitoneal 2050mg/kg (2050mg/kg)   Radiation Research. Vol. 109, Pg. 479, 1987.
mouse LD50 oral 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. 6, Pg. 545, 1982.
mouse LD50 subcutaneous 2gm/kg (2000mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 19, Pg. 48, 1946.
rat LD50 oral 3500mg/kg (3500mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1390, 1986.
rat LD50 subcutaneous 1680mg/kg (1680mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 19, 1946.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 130 deg C   EXP
pKa Dissociation Constant 3.35 (none) 20 EXP
log P (octanol-water) -0.37 (none)   EXP
Water Solubility 5.00E+05 mg/L 25 EXP
Vapor Pressure 4.20E-04 mm Hg 25 EST
Henry's Law Constant 2.90E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.34E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.