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Substance Name: Kallidinogenase [INN:BAN:JAN]
RN: 9001-01-8
UNII: OT9M1PSK9N

Notes

  • A family of trypsin-like SERINE ENDOPEPTIDASES that are expressed in a variety of cell types including human prostate epithelial cells. They are formed from tissue prokallikrein by action with TRYPSIN. They are highly similar to PROSTATE-SPECIFIC ANTIGEN. EC 3.4.21.35.
  • A peptidohydrolytic enzyme that is formed from PREKALLIKREIN by FACTOR XIIA. It activates FACTOR XII; FACTOR VII; and PLASMINOGEN. It is selective for both ARGININE and to a lesser extent LYSINE bonds. EC 3.4.21.34.
  • Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).
 

Classification Codes

  • Coagulants
  • Drug / Therapeutic Agent
  • Fertility Agents, Male
  • Hematologic Agents
  • Mutation Data
  • Reproductive Control Agents
  • Reproductive Effect
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Links to Resources

Names and Synonyms

Name of Substance

  • Kallidinogenase [INN:BAN:JAN]

MeSH Headings

  • Kallikreins
  • Plasma Kallikrein

Synonyms

  • Bradykini
  • Callicrein
  • Depot-padutin
  • Dilminal D
  • E.C. 3.4.21.8
  • E.C. 3.4.4.21
  • EINECS 232-574-5
  • Glumorin
  • Kalidinogenasa
  • Kalidinogenasa [INN-Spanish]
  • Kallidinogenase
  • Kallidinogenasum
  • Kallidinogenasum [INN-Latin]
  • Kallikrein
  • Kininogenase
  • Kininogenin
  • Onokrein P
  • Padreatin
  • Padutin
  • Pancreatic kallikrein
  • SK-827
  • UNII-OT9M1PSK9N
  • Urinary kallikrein
  • Urokallikrein

Systematic Names

  • Enzyme isolated from the pancreas or urine of mammals
  • Kallikrein

Registry Numbers

CAS Registry Number

  • 9001-01-8

FDA UNII

  • OT9M1PSK9N

System Generated Number

  • 0009001018

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous > 40mL/kg (40mL/kg)   Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2589, 1993.
mouse LD50 oral > 40mL/kg (40mL/kg)   Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2589, 1993.
mouse LD50 subcutaneous > 40mL/kg (40mL/kg)   Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2589, 1993.
rat LD50 intravenous > 40mL/kg (40mL/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2589, 1993.
rat LD50 oral > 40mL/kg (40mL/kg)   Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2589, 1993.
rat LD50 subcutaneous > 40mL/kg (40mL/kg)   Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2589, 1993.