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Substance Name: Dextran sulfate sodium [JAN]
RN: 9042-14-2

Note

  • Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.

Molecular Formula

  • H2-O4-S.x-Unspecified
 

Classification Code

  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Names and Synonyms

Name of Substance

  • Dextran sulfate
  • Dextran sulfate sodium [JAN]

MeSH Heading

  • Dextran sulfate

Synonyms

  • Asuro
  • Bicibon
  • Colyonal
  • Dextran natrium-sulfat
  • Dextran polysulfate
  • Dextran sulfate
  • Dextran sulfate 500
  • Dextran sulfate sodium
  • Dextran sulfuric acid
  • Dextran sulfuric acid ester
  • Dextran sulphate
  • Macrodex
  • PF 51
  • Polydextran sulfate
  • UNII-01W9V5H5WO
  • UNII-AIW09WL51K
  • UNII-NXV22KT7NQ
  • UNII-V5LWP0C2L5

Systematic Name

  • Dextran, hydrogen sulfate

Registry Numbers

CAS Registry Number

  • 9042-14-2

FDA UNIIs

  • 01W9V5H5WO
  • AIW09WL51K
  • NXV22KT7NQ
  • V5LWP0C2L5

Other Registry Numbers

  • 191288-77-4
  • 37271-05-9
  • 50935-34-7
  • 73075-68-0
  • 9057-27-6
  • 9063-02-9

System Generated Number

  • 0009042142

Molecular Formulas

Molecular Formula

  • H2-O4-S.x-Unspecified

Molecular Formula Fragments

  • COMPONENT
  • H2-O4-S
  • Unspecified

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 2500mg/kg (2500mg/kg)   Journal of Medicinal Chemistry. Vol. 30, Pg. 810, 1987.
mouse LD50 intraperitoneal 341mg/kg (341mg/kg)   Drug Delivery System. Vol. 14, Pg. 407, 1999.