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Substance Name: Finasteride [USAN:USP:INN:BAN]
RN: 98319-26-7
UNII: 57GNO57U7G
InChIKey: DBEPLOCGEIEOCV-WSBQPABSSA-N
Note
- An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.
Molecular Formula
- C23-H36-N2-O2
Molecular Weight
- 372.5494
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- 5-alpha Reductase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Hormone Antagonists
- Inhibitor (alpha Reductase)
- Reproductive Effect
- Steroid Synthesis Inhibitors
- Urological Agents
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Names and Synonyms
Name of Substance
- Finasteride
- Finasteride [USAN:USP:INN:BAN]
MeSH Heading
- Finasteride
Synonyms
- (5alpha,17beta)-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
- 17beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androst-1-en-3-one
- 4-Azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5alpha,17beta)-
- BRN 4269024
- CCRIS 7438
- Chibro-Proscar
- Finasterida
- Finasterida [INN-Spanish]
- Finasteride
- Finasteridum
- Finasteridum [INN-Latin]
- Finastid
- Finpecia
- HSDB 6793
- L-652,931
- MK 0906
- MK 906
- MK-0906
- MK-906
- N-(2-Methyl-2-propyl)-3-oxo-4-aza-5-alpha-androst-1-ene-17-beta-carboxamide
- N-tert-Butyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
- NSC 741485
- NSC 759318
- Propecia
- Proscar
- Prostide
- UNII-57GNO57U7G
Systematic Names
- 4-Azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5alpha,17beta)-
- Finasteride
Registry Numbers
CAS Registry Number
- 98319-26-7
FDA UNII
- 57GNO57U7G
System Generated Number
- 0098319267
Structure Descriptors
InChI
InChI=1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1InChIKey
DBEPLOCGEIEOCV-WSBQPABSSA-NSmiles
CC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | > 1gm/kg (1000mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994. |
mouse | LD50 | intraperitoneal | 372mg/kg (372mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994. |
mouse | LD50 | oral | 486mg/kg (486mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994. |
mouse | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994. | |
rat | LD50 | intraperitoneal | 885mg/kg (885mg/kg) | GASTROINTESTINAL: PERITONITIS GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994. |
rat | LD50 | oral | 418mg/kg (418mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994. |
rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4091, 1994. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 252-254 | deg C | EXP | |
log P (octanol-water) | 3.03 | (none) | EXP | |
Water Solubility | 11.7 | mg/L | 25 | EST |
Vapor Pressure | 7.47E-12 | mm Hg | 25 | EST |
Henry's Law Constant | 3.77E-11 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 5.55E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.