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Substance Name: Lacidipine [USAN:INN:BAN]
RN: 103890-78-4
UNII: 260080034N
InChIKey: GKQPCPXONLDCMU-CCEZHUSRSA-N

Classification Codes

  • Antihypertensive
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Calcium-Regulating Hormones and Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Reproductive Effect

Molecular Formula

  • C26-H33-N-O6

Molecular Weight

  • 455.5477
 
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Names and Synonyms

Name of Substance

  • Lacidipine
  • Lacidipine [USAN:INN:BAN]

Synonyms

  • 3,5-Pyridinedicarboxylic acid, 4-(2-(3-(1,1-dimethylethoxy)-3-oxo-1-propenyl)phenyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester, (E)-
  • 4-(o-((E)-2-Carboxyvinyl)phenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 4-tert-butyl diethyl ester
  • GR 43659 X
  • GR 43659X
  • Lacidipine
  • Lacidipino
  • Lacidipino [Spanish]
  • Lacidipinum
  • Lacidipinum [Latin]
  • Lacimen
  • Lacipil
  • Motens
  • UNII-260080034N

Systematic Names

  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-(3-(1,1-dimethylethoxy)-3-oxo-1-propenyl)phenyl)-, diethyl ester, (E)-
  • 3,5-Pyridinedicarboxylic acid, 4-(2-(3-(1,1-dimethylethoxy)-3-oxo-1-propenyl)phenyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester, (E)-

Registry Numbers

CAS Registry Number

  • 103890-78-4

FDA UNII

  • 260080034N

System Generated Number

  • 0103890784

Structure Descriptors

InChI

InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+

InChIKey

GKQPCPXONLDCMU-CCEZHUSRSA-N

Smiles

CCOC(=O)C1=C(C)NC(=C(C1c2ccccc2\C=C\C(=O)OC(C)(C)C)C(=O)OCC)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 80200ug/kg (80.2mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
mouse LD50 oral 3150mg/kg (3150mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
rat LD50 intraperitoneal 43300ug/kg (43.3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
rat LD50 oral 880mg/kg (880mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
rat LD50 subcutaneous 562mg/kg (562mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: OTHER CHANGES 		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 5.2 (none)   EXP
Water Solubility 0.507 mg/L 25 EST
Vapor Pressure 2.16E-10 mm Hg 25 EST
Henry's Law Constant 5.87E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.39E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.