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Substance Name: EPOCH regimen
ID: C079446000
InChIKey: SGQFWAXIZQKBSE-CLMURDHLSA-N

Note

  • Chemotherapy regimen used to treat patients with chemotherapy-resistant Hodgkin's disease & non-Hodgkin's lymphoma; also used in the treatment of aggressive cytophagic histiocytic panniculitis.

    NCI: A chemotherapy regimen consisting of etoposide, prednisone, vincristine (Oncovin) and doxorubicin hydrochloride (hydroxydaunorubicin hycrochloride), which may be used in combination with rituximab (R-EPOCH) for the treatment of various aggressive B cell and T cell non-Hodgkin lymphomas. (NCI Thesaurus)

Molecular Weight

  • 2576.5662
 
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Names and Synonyms

Results Name

  • EPOCH regimen

Name of Substance

  • EPOCH protocol

Synonyms

  • Cyclophosphamide regimen with etoposide, hydroxydaunorubicin, oncovin and prednisone
  • EPOCH
  • EPOCH [regimen]
  • Etoposide / Prednisone / Oncovin / Cyclophosphamide / Hydroxydaunorubicin regimen
  • Etoposide-Prednisone-Oncovin-Cyclophosphamide-Hydroxydaunorubicin regimen

Registry Number

  • C079446000

Structure Descriptors

InChI

1S/C46H56N4O10.C29H32O13.C27H29NO11.C21H26O5.C7H15Cl2N2O2P/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(16-20-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-15-14-31-34(35(32)57-4)50(26-51)38-44(31)18-21-49-19-11-17-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3;1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19;8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h9-15,17,26,28,37-39,47,55-56H,7-8,16,18-25H2,1-6H3;4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3;3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3;1-7H2,(H,10,12)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;11-,15+,20-,21-,22+,24-,25-,26?,27-,29+;10-,13-,15-,17-,22+,27-;14-,15-,18+,19-,20-,21-;/m0100./s1

InChIKey

SGQFWAXIZQKBSE-CLMURDHLSA-N

Smiles

[C@@H]1(C[C@@H]([C@@H]([C@@H](O1)C)O)N)O[C@@H]1c2c(C[C@](C1)(C(=O)CO)O)c(c1c(c2O)C(=O)c2c(C1=O)cccc2OC)O.[C@@H]12CC[C@]([C@]1(CC(=O)[C@@H]1[C@@]3(C(=CC(=O)C=C3)CC[C@@H]21)C)C)(O)C(=O)CO.c1(cc(c(c(c1)OC)O)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2C(c2cc3c(OCO3)cc12)O[C@H]1[C@@H]([C@H]([C@H]2[C@H](O1)CO[C@H](O2)C)O)O.N12[C@H]3[C@@](C=CC1)([C@H]([C@]([C@H]1[C@@]3(c3c(N1C=O)c(c(cc3)[C@@]1(C3=[C@@H](c4c(N3)cccc4)CCN3C[C@@H](C[C@@](C3)(O)CC)C1)C(=O)OC)OC)CC2)(O)C(=O)OC)OC(=O)C)CC.N(CCCl)(P1(=O)OCCCN1)CCCl