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Substance Name: MOPPEBVCAD regimen
ID: C507380000
InChIKey: ZTDIQLZKKLALFM-CRHKGKFQSA-O

Notes

  • When associated with conditioned and limited (not adjuvant) radiotherapy, ABVD and MOPPEBVCAD /Bleomycin, Doxorubicin, Lomustine, Mechlorethamine, Melphalan, Prednisone, Procarbazine, Vinblastine, Vincristine, Vindesine/ were superior to Stanford V chemotherapy in terms of response rate and FFS and progression-free survival. Patients were irradiated less often after MOPPEBVCAD, but this regimen was more toxic. ABVD is still the best choice when it is combined with optional, limited irradiation. When associated with conditioned and limited (not adjuvant) radiotherapy, ABVD and MOPPEBVCAD were superior to Stanford V chemotherapy in terms of response rate and FFS and progression-free survival. Patients were irradiated less often after MOPPEBVCAD, but this regimen was more toxic. ABVD is still the best choice when it is combined with optional, limited irradiation.
  • When associated with conditioned and limited (not adjuvant) radiotherapy, ABVD and MOPPEBVCAD were superior to Stanford V chemotherapy in terms of response rate and FFS and progression-free survival. Patients were irradiated less often after MOPPEBVCAD, but this regimen was more toxic. ABVD is still the best choice when it is combined with optional, limited irradiation.

Molecular Weight

  • 5863.9955
 
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Names and Synonyms

Results Name

  • MOPPEBVCAD regimen

Name of Substance

  • MOPPEBVCAD protocol

Synonyms

  • MOPPEBVCAD
  • MOPPEBVCAD regimen

Registry Number

  • C507380000

Structure Descriptors

InChI

1S/C55H83N17O21S3.C46H56N4O10.C46H58N4O9.C43H57N5O7.2C27H29NO11.C21H26O5.C12H19N3O.C9H16ClN3O2.C5H11Cl2N/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-7-42(55)22-28-23-45(40(53)58-5,36-30(16-20-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-15-14-31-34(35(32)57-4)50(26-51)38-44(31)18-21-49-19-11-17-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-8-42(54)23-28-24-45(40(52)57-6,36-30(17-21-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-16-15-31-34(35(32)56-5)48(4)38-44(31)19-22-50-20-12-18-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-6-40(52)21-24-22-47(23-40)17-13-26-25-11-8-9-12-29(25)45-34(26)33(35(49)55-5)32(24)27-19-28-30(20-31(27)54-4)46(3)37-42(28)15-18-48-16-10-14-41(7-2,36(42)48)38(50)43(37,53)39(44)51;2*1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19;1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8;1-8(4-2-6)5-3-7/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);9-15,17,26,28,37-39,47,55-56H,7-8,16,18-25H2,1-6H3;10-16,18,28,37-39,47,54-55H,8-9,17,19-26H2,1-7H3;8-12,14,19-20,24,26,32-34,36-38,45,50,52-53H,6-7,13,15-18,21-23H2,1-5H3,(H2,44,51);2*3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3;4-7,9,13-14H,8H2,1-3H3,(H,15,16);8H,1-7H2,(H,11,14);2-5H2,1H3/p+1/t21-,22+,23+,24-,25-,29-,30+,34-,35-,36-,37+,38+,39-,40+,41?,42-,43-,53+,54-;2*28-,37-,38+,39+,42-,43+,44+,45-,46-;24-,26?,32+,33+,34?,36-,37+,38+,40-,41+,42+,43-;10-,13-,15-,17-,22+,27-;10-,13-,15-,17-,22-,27-;14-,15-,18+,19-,20-,21-;;;/m0000000.../s1

InChIKey

ZTDIQLZKKLALFM-CRHKGKFQSA-O

Smiles

c1(c2csc(n2)CCNC(=O)[C@@H](NC(=O)[C@H]([C@H](O)[C@H](NC(=O)[C@@H](NC(=O)c2c(c(nc([C@@H](NC[C@@H](C(=O)N)N)CC(=O)N)n2)N)C)C(O[C@@H]2O[C@H]([C@@H](O)[C@H](O)[C@@H]2O[C@H]2O[C@@H]([C@@H](O)[C@H](OC(=O)N)[C@H]2O)CO)CO)c2cnc[nH]2)C)C)[C@H](O)C)scc(n1)C(=O)NCCC[S+](C)C.ClCCN(CCCl)C.N12[C@H]3[C@@](C=CC1)([C@H]([C@]([C@H]1[C@@]3(c3c(N1C=O)c(c(cc3)[C@@]1(C3=[C@@H](c4c(N3)cccc4)CCN3C[C@@H](C[C@@](C3)(O)CC)C1)C(=O)OC)OC)CC2)(O)C(=O)OC)OC(=O)C)CC.N12[C@H]3[C@@](C=CC1)([C@H]([C@]([C@H]1[C@@]3(c3c(N1C)c(c(cc3)[C@@]1(C3=[C@@H](c4c(N3)cccc4)CCN3C[C@@H](C[C@@](C3)(O)CC)C1)C(=O)OC)OC)CC2)(O)C(=O)OC)OC(=O)C)CC.[C@@H]1(C[C@@H]([C@H]([C@@H](O1)C)O)N)O[C@@H]1c2c(C[C@](C1)(C(=O)CO)O)c(c1c(c2O)C(=O)c2c(C1=O)cccc2OC)O.[C@@H]1(C[C@@H]([C@@H]([C@@H](O1)C)O)N)O[C@@H]1c2c(C[C@](C1)(C(=O)CO)O)c(c1c(c2O)C(=O)c2c(C1=O)cccc2OC)O.[C@@H]12CC[C@]([C@]1(CC(=O)[C@@H]1[C@@]3(C(=CC(=O)C=C3)CC[C@@H]21)C)C)(O)C(=O)CO.C1(NC(=O)N(CCCl)N=O)CCCCC1.[C@]123[C@H]([C@]([C@@H]([C@]4([C@@H]1N(CC=C4)CC3)CC)O)(C(=O)N)O)N(c1c2cc(c(c1)OC)[C@H]1[C@H]2C[C@](CN(C2)CCC2C([C@@H]1C(=O)OC)Nc1c2cccc1)(CC)O)C.CNNCc1ccc(C(=O)NC(C)C)cc1