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Substance Name: VAMP Regimen
ID: S900005570
InChIKey: ATCJTYORYKLVIA-SRXJVYAUSA-N

Note

  • Used in therapy of non-Hodgkin's lymphoma.

    NCI: A chemotherapy regimen consisting of vincristine, doxorubicin hydrochloride (Adriamycin), methotrexate and prednisone used in combination with radiation therapy for the treatment of low-risk childhood Hodgkin lymphoma. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Molecular Weight

  • 2183.3805
 

Classification Code

  • Antineoplastic Agents
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Names and Synonyms

Name of Substance

  • VAMP Protocol
  • VAMP Regimen

Synonyms

  • Adriamycin regimen with methotrexate, prednisone and vincristine
  • Doxorubicin hydrochloride regimen with methotrexate, prednisone and vincristine
  • VAMP
  • Vincristine-Adriamycin-methotrexate-prednisone regimen

Registry Number

  • S900005570

Structure Descriptors

InChI

1S/C46H56N4O10.C27H29NO11.C21H28O5.C20H22N8O5/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19;1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3;2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t28-,37-,38+,39+,42-,43+,44?,45-,46-;10-,13-,15-,17-,22+,27-;14-,15-,16-,18+,19-,20-,21-;13-/m0000/s1

InChIKey

ATCJTYORYKLVIA-SRXJVYAUSA-N

Smiles

CC[C@@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)CC[N@](C2)C1)(c5cc6c(cc5OC)N([C@@H]7C68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)OC)O)OC(=O)C)CC)C=O)C(=O)OC)O.C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](Cc3c2c(c4c(c3O)C(=O)c5cccc(c5C4=O)OC)O)(C(=O)CO)O)N)O.C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O.CN(Cc1cnc2c(n1)c(nc(n2)N)N)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O