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Substance Name: AGEN1884
ID: S900007370


  • NCI: anti-CTLA-4 monoclonal antibody AGEN1884 A recombinant human monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CTLA4 monoclonal antibody AGEN1884 binds to CTLA4 expressed on T cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system.
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Names and Synonyms

Name of Substance

  • AGEN1884


  • AGEN 1884

Registry Number

  • S900007370