Skip Navigation
ChemIDplus LiteBrowseAdvanced

Substance Name: LXH254
ID: S900007460

Note

  • NCI: pan-Raf inhibitor LXH254. An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon administration, pan-RAF inhibitor LXH254 binds to Raf proteins and inhibits Raf-mediated signal transduction pathways. This inhibits proliferation of Raf-overexpressing tumor cells. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. They play key roles in tumor cell proliferation and survival. (NCI Thesaurus)
 
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)

Names and Synonyms

Name of Substance

  • LXH254

Synonyms

  • LXH 254
  • LXH-254

Registry Number

  • S900007460