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Substance Name: Axicabtagene ciloleucel
ID: S900007630

Note

  • NCI: anti-CD19/CD28/CD3zeta CAR gammaretroviral vector-transduced autologous T lymphocytes KTE-C19 A preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been transduced with a gammaretroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3 zeta), with potential immunostimulating and antineoplastic activities. Upon intravenous infusion and re-introduction of the anti-CD19/CD28/CD3zeta CAR gammaretroviral vector-transduced autologous T lymphocytes KTE-C19 into the patient, these cells bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen that is expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the TCR/CD3 complex; it regulates both the assembly and cell surface expression of TCR complexes. CD28 is essential for CD4 T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development. (NCI Thesaurus)
 

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic Agents, Immunological
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Names and Synonyms

Name of Substance

  • Axicabtagene ciloleucel

Synonyms

  • KTE-C19
  • Yescarta

Registry Number

  • S900007630