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Substance Name: Huperzine A
RN: 102518-79-6
UNII: 0111871I23
InChIKey: ZRJBHWIHUMBLCN-YQEJDHNASA-N

Classification Codes

  • Central Nervous System Agents
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Neuroprotective Agents
  • Neurotransmitter Agents
  • Protective Agents

Molecular Formula

  • C15-H18-N2-O

Molecular Weight

  • 242.3202
 
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Names and Synonyms

Name of Substance

  • Huperzine A

Synonyms

  • (-)-Huperazine A
  • (-)-Selagine
  • Hup A
  • Huperzine A
  • Kimpukan A
  • Selagine
  • UNII-0111871I23

Systematic Names

  • 5,9-Methanocycloocta(b)pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-
  • 5,9-Methanocycloocta(b)pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R-(5-alpha,9-beta,11E))-

Registry Numbers

CAS Registry Number

  • 102518-79-6

FDA UNII

  • 0111871I23

Other Registry Numbers

  • 116-28-9
  • 1369-64-8

System Generated Number

  • 0102518796

Structure Descriptors

InChI

1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1

InChIKey

ZRJBHWIHUMBLCN-YQEJDHNASA-N

Smiles

C/C=C/1\[C@@H]2Cc3c(ccc(=O)[nH]3)[C@]1(CC(=C2)C)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intramuscular 1200ug/kg (1.2mg/kg)   Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 3, Pg. 246, 1989.
mouse LD50 intraperitoneal 1793ug/kg (1.793mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 8, Pg. 117, 1987.
mouse LD50 intravenous 630ug/kg (0.63mg/kg)   United States Patent Document. Vol. #5177082,
mouse LD50 oral 5200ug/kg (5.2mg/kg)   United States Patent Document. Vol. #5177082,
mouse LD50 subcutaneous 3mg/kg (3mg/kg)   United States Patent Document. Vol. #5177082,
rat LD50 intraperitoneal 2472ug/kg (2.472mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 8, Pg. 117, 1987.
rat LD50 intravenous 2500ug/kg (2.5mg/kg)   United States Patent Document. Vol. #5177082,
rat LD50 oral 15mg/kg (15mg/kg)   Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 3, Pg. 246, 1989.