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Substance Name: Thiamylal [USP]
RN: 77-27-0
UNII: 01T23W89FR


  • A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)

Molecular Formula

  • C12-H18-N2-O2-S

Molecular Weight

  • 254.3522

Classification Codes

Classification Codes

  • Anesthetic (Intravenous)
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, Intravenous
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • GABA Agents
  • GABA Modulators
  • Hypnotics and Sedatives
  • Neurotransmitter Agents

Superlist Classification Code

  • DEA Schedule III
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Names and Synonyms

Name of Substance

  • Thiamylal
  • Thiamylal [USP]

MeSH Heading

  • Thiamylal


  • 5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid
  • 5-Allyl-5-(1-methylbutyl)-2-thiobarbitursaeure
  • EINECS 201-018-3
  • NSC 120815
  • Thiamylal
  • Thioseconal
  • UNII-01T23W89FR

Systematic Names

  • 4,6(1H,5H)-Pyrimidinedione, dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo- (9CI)
  • 5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid
  • Barbituric acid, 5-allyl-5-(1-methylbutyl)-2-thio- (VAN) (8CI)
  • Dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6-(1H,5H)-pyrimidinedione

Superlist Names

  • DEA No. 2100
  • Surital
  • Thiamylal

Registry Numbers

CAS Registry Number

  • 77-27-0


  • 01T23W89FR

Other Registry Numbers

  • 1340-07-4
  • 7187-63-5

System Generated Number

  • 0000077270

Structure Descriptors







Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 132-133 deg C   EXP
pKa Dissociation Constant 7.48 (none)   EXP
log P (octanol-water) 3.23 (none)   EXP
Water Solubility 49.4 mg/L 25 EXP
Vapor Pressure 9.99E-11 mm Hg 25 EST
Henry's Law Constant 6.28E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.31E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.