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Substance Name: Albuterol sulfate [USAN:USP]
RN: 51022-70-9
UNII: 021SEF3731
InChIKey: BNPSSFBOAGDEEL-UHFFFAOYSA-N

Note

  • A racemic mixture with a 1:1 ratio of the r-isomer, levalbuterol, and s-albuterol. It is a short-acting beta2-adrenergic agonist with its main clinical use in ASTHMA.

Molecular Formula

  • C13-H21-N-O3.1/2H2-O4-S

Molecular Weight

  • 576.7036
 

Classification Codes

  • Bronchodilator
  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Albuterol sulfate [USAN:USP]

Synonyms

  • (+-)-Salbutamol sulfate
  • 1,3-Benzenedimethanol, alpha(sup 1)-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, sulfate (2:1) (salt)
  • 1-(4-Hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanol sulfate
  • AccuNeb
  • Aerotec
  • Albuterol sulfate
  • Aloprol
  • alpha(sup 1)-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-alpha,alpha'-diol sulfate (2:1) (salt)
  • Amocasin
  • Broncho Inhalat
  • Bronchospray
  • Broncodil
  • Dipulmin
  • dl-Salbutamol sulfate
  • EINECS 256-916-8
  • Emican
  • Epaq
  • Fartolin
  • Huma-Salmol
  • Inspiryl
  • Loftan
  • NSC 289928
  • Proair
  • Proair HFA
  • Proair Respiclick
  • Proventil
  • Proventil Repetabs, Solution, Syrup, and Tablets
  • Proventil-HFA
  • Salbutamol hemisulfate
  • Salbutamol sulfate
  • Sch 13949W sulfate
  • UNII-021SEF3731
  • Venetlin
  • Ventolin
  • Ventolin HFA
  • Ventolin Rotacaps
  • Volmax
  • Vospire ER

Systematic Names

  • 1,3-Benzenedimethanol, alpha(sup 1)-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, sulfate (2:1) (salt)
  • 1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, sulfate (2:1) (salt)
  • Bis((tert-butyl)(beta,3,4-trihydroxyphenethyl)ammonium) sulphate

Mixture Names

  • Arm-A-Med
  • Combivent

Registry Numbers

CAS Registry Number

  • 51022-70-9

FDA UNII

  • 021SEF3731

Other Registry Number

  • 36519-31-0

System Generated Number

  • 0051022709

Molecular Formulas

Molecular Formula

  • C13-H21-N-O3.1/2H2-O4-S

Molecular Formula Fragments

  • C13-H21-N-O3
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

InChI=1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)

InChIKey

BNPSSFBOAGDEEL-UHFFFAOYSA-N

Smiles

CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c2ccc(O)c(CO)c2.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 76mg/kg (76mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 276, 1980.
guinea pig LD50 oral 4839mg/kg (4839mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 276, 1980.
mouse LD50 intraperitoneal 200mg/kg (200mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 40, Pg. 42, 1977.
mouse LD50 intravenous 48700ug/kg (48.7mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 2, Pg. 128, 1971.
mouse LD50 intravenous 49200ug/kg (49.2mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 276, 1980.
mouse LD50 oral 1950mg/kg (1950mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 40, Pg. 42, 1977.
mouse LD50 oral 4724mg/kg (4724mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SKIN AND APPENDAGES (SKIN): HAIR: OTHER		 Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 276, 1980.
mouse LD50 subcutaneous 737mg/kg (737mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 2, Pg. 128, 1971.
rat LD50 intraperitoneal 295mg/kg (295mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 2, Pg. 128, 1971.
rat LD50 intravenous 59100ug/kg (59.1mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 2, Pg. 128, 1971.
rat LD50 oral > 2500mg/kg (2500mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 2, Pg. 128, 1971.
rat LD50 subcutaneous > 2500mg/kg (2500mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 2, Pg. 128, 1971.