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Substance Name: Tinidazole [USAN:USP:INN:BAN:JAN]
RN: 19387-91-8
UNII: 033KF7V46H
InChIKey: HJLSLZFTEKNLFI-UHFFFAOYSA-N

Note

  • A nitroimidazole alkylating agent that is used as an antitrichomonal agent against TRICHOMONAS VAGINALIS; ENTAMOEBA HISTOLYTICA; and GIARDIA LAMBLIA infections. It also acts as an antibacterial agent for the treatment of BACTERIAL VAGINOSIS and anaerobic bacterial infections.

Molecular Formula

  • C8-H13-N3-O4-S

Molecular Weight

  • 247.2737
 

Classification Codes

  • Alkylating Agents
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Antiprotozoal
  • Antiprotozoal Agents
  • Antitrichomonal Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Noxae
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Tinidazole
  • Tinidazole [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Tinidazole

Synonyms

  • 1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitroimidazole
  • 1H-Imidazole, 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-
  • 5-23-05-00067 (Beilstein Handbook Reference)
  • Amtiba
  • Bioshik
  • BRN 0618182
  • CCRIS 7621
  • CP 12574
  • CP-12,574
  • EINECS 243-014-4
  • Ethyl (2-(2-methyl-5-nitro-1-imidazolyl)ethyl)sulfone
  • Fasigin
  • Fasigyn
  • Glongyn
  • HSDB 7362
  • NSC 758189
  • Pletil
  • Protozol
  • Simplotan
  • Sorquetan
  • Tindamax
  • Tinidazol
  • Tinidazol [INN-Spanish]
  • Tinidazole
  • Tinidazolum
  • Tinidazolum [INN-Latin]
  • Tricolam
  • Trimonase
  • UNII-033KF7V46H

Systematic Names

  • 1H-Imidazole, 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-
  • Imidazole, 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-
  • Tinidazole

Registry Numbers

CAS Registry Number

  • 19387-91-8

FDA UNII

  • 033KF7V46H

System Generated Number

  • 0019387918

Structure Descriptors

InChI

InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3

InChIKey

HJLSLZFTEKNLFI-UHFFFAOYSA-N

Smiles

CCS(=O)(=O)CCn1c(C)ncc1[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 2gm/kg (2000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1313, 1980.
mouse LD50 intraperitoneal 2730mg/kg (2730mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974.
mouse LD50 intravenous > 250mg/kg (250mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Yakkyoku. Pharmacy. Vol. 32, Pg. 204, 1981.
mouse LD50 oral 3200mg/kg (3200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR		 Journal of Medicinal Chemistry. Vol. 21, Pg. 781, 1978.
mouse LD50 subcutaneous 3940mg/kg (3940mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974.
rat LD50 intraperitoneal 2720mg/kg (2720mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974.
rat LD50 intravenous > 250mg/kg (250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Yakkyoku. Pharmacy. Vol. 32, Pg. 204, 1981.
rat LD50 oral 2710mg/kg (2710mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974.
rat LD50 subcutaneous 3gm/kg (3000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 127-128 deg C   EXP
log P (octanol-water) -0.35 (none)   EXP
Water Solubility 1.99E+04 mg/L 25 EST
Vapor Pressure 7.87E-08 mm Hg 25 EST
Henry's Law Constant 5.21E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.16E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.