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Substance Name: Tinidazole [USAN:USP:INN:BAN:JAN]
RN: 19387-91-8
UNII: 033KF7V46H
InChIKey: HJLSLZFTEKNLFI-UHFFFAOYSA-N
Note
- A nitroimidazole alkylating agent that is used as an antitrichomonal agent against TRICHOMONAS VAGINALIS; ENTAMOEBA HISTOLYTICA; and GIARDIA LAMBLIA infections. It also acts as an antibacterial agent for the treatment of BACTERIAL VAGINOSIS and anaerobic bacterial infections.
Molecular Formula
- C8-H13-N3-O4-S
Molecular Weight
- 247.2737
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Alkylating Agents
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antiparasitic Agents
- Antiprotozoal
- Antiprotozoal Agents
- Antitrichomonal Agents
- Drug / Therapeutic Agent
- Mutation Data
- Noxae
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Tinidazole
- Tinidazole [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Tinidazole
Synonyms
- 1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitroimidazole
- 1H-Imidazole, 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-
- 5-23-05-00067 (Beilstein Handbook Reference)
- Amtiba
- Bioshik
- BRN 0618182
- CCRIS 7621
- CP 12574
- CP-12,574
- EINECS 243-014-4
- Ethyl (2-(2-methyl-5-nitro-1-imidazolyl)ethyl)sulfone
- Fasigin
- Fasigyn
- Glongyn
- HSDB 7362
- NSC 758189
- Pletil
- Protozol
- Simplotan
- Sorquetan
- Tindamax
- Tinidazol
- Tinidazol [INN-Spanish]
- Tinidazole
- Tinidazolum
- Tinidazolum [INN-Latin]
- Tricolam
- Trimonase
- UNII-033KF7V46H
Systematic Names
- 1H-Imidazole, 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-
- Imidazole, 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-
- Tinidazole
Registry Numbers
CAS Registry Number
- 19387-91-8
FDA UNII
- 033KF7V46H
System Generated Number
- 0019387918
Structure Descriptors
InChI
InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3InChIKey
HJLSLZFTEKNLFI-UHFFFAOYSA-NSmiles
CCS(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | oral | 2gm/kg (2000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1313, 1980. | |
mouse | LD50 | intraperitoneal | 2730mg/kg (2730mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974. |
mouse | LD50 | intravenous | > 250mg/kg (250mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakkyoku. Pharmacy. Vol. 32, Pg. 204, 1981. |
mouse | LD50 | oral | 3200mg/kg (3200mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR | Journal of Medicinal Chemistry. Vol. 21, Pg. 781, 1978. |
mouse | LD50 | subcutaneous | 3940mg/kg (3940mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974. |
rat | LD50 | intraperitoneal | 2720mg/kg (2720mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974. |
rat | LD50 | intravenous | > 250mg/kg (250mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Yakkyoku. Pharmacy. Vol. 32, Pg. 204, 1981. |
rat | LD50 | oral | 2710mg/kg (2710mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974. |
rat | LD50 | subcutaneous | 3gm/kg (3000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 127-128 | deg C | EXP | |
log P (octanol-water) | -0.35 | (none) | EXP | |
Water Solubility | 1.99E+04 | mg/L | 25 | EST |
Vapor Pressure | 7.87E-08 | mm Hg | 25 | EST |
Henry's Law Constant | 5.21E-11 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.16E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.