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Substance Name: Zopiclone [INN:BAN:JAN]
RN: 43200-80-2
UNII: 03A5ORL08Q
InChIKey: GBBSUAFBMRNDJC-UHFFFAOYSA-N
Note
- S(+)-enantiomer of racemic zopiclone; azabicyclo(4.3.0)nonane; a nonbenzodiazepine; one of the so-called of Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) for which there is some correlation with tumors.
Molecular Formula
- C17-H17-Cl-N6-O3
Molecular Weight
- 388.8133
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Central Nervous System Agents
- Central Nervous System Depressants
- Hypnotics and Sedatives
- Mutation Data
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Zopiclone
- Zopiclone [INN:BAN:JAN]
Synonyms
- (+-)-Zopiclone
- 27267 R.P.
- 4-Methyl-1-piperazinecarboxylic acid ester with 6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo(3,4-b)pyrazin-5-one
- Amoban
- Amovane
- BRN 0768704
- EINECS 256-138-9
- Imovane
- NSC 758463
- RP 27267
- UNII-03A5ORL08Q
- Zopiclona
- Zopiclona [INN-Spanish]
- Zopiclone
- Zopiclonum
- Zopiclonum [INN-Latin]
Systematic Names
- 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester
- 4-Methyl-1-piperazinecarboxylic acid ester with 6-(5-chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo(3,4-b)pyrazin-5-one
- Zopiclone
Superlist Names
- DEA No. 2784
- Zopiclone
Registry Numbers
CAS Registry Number
- 43200-80-2
FDA UNII
- 03A5ORL08Q
Other Registry Number
- 138680-07-6
System Generated Number
- 0043200802
Structure Descriptors
InChI
InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3InChIKey
GBBSUAFBMRNDJC-UHFFFAOYSA-NSmiles
CN1CCN(CC1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intramuscular | 541mg/kg (541mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. |
mouse | LD50 | intraperitoneal | 1325mg/kg (1325mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. |
mouse | LD50 | intravenous | 321mg/kg (321mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. |
mouse | LD50 | oral | 2174mg/kg (2174mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. |
mouse | LD50 | subcutaneous | 888mg/kg (888mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. |
rat | LD50 | intramuscular | 295mg/kg (295mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. |
rat | LD50 | intraperitoneal | 771mg/kg (771mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. | |
rat | LD50 | intraperitoneal | 771mg/kg (771mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. |
rat | LD50 | intravenous | 280mg/kg (280mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. |
rat | LD50 | oral | 827mg/kg (827mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. |
rat | LD50 | subcutaneous | 540mg/kg (540mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. | |
rat | LD50 | subcutaneous | 540mg/kg (540mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 935, 1983. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 178 | deg C | EXP | |
log P (octanol-water) | 1.540 | (none) | EST | |
Atmospheric OH Rate Constant | 1.34E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.