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Substance Name: Mometasone furoate [USAN:USP:JAN]
RN: 83919-23-7
UNII: 04201GDN4R


  • A pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for skin disorders.
  • NCI: Mometasone furoate. The furoate salt form of mometasone, a synthetic topical glucocorticosteroid receptor agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Mometasone furoate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators.. Specifically, mometasone furoate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2. (NCI Thesaurus)

Molecular Formula

  • C27-H30-Cl2-O6

Molecular Weight

  • 521.434

Classification Codes

  • Anti-Allergic Agents
  • Anti-Inflammatory Agents
  • Dermatologic Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect
  • Steroid (Topical)
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Names and Synonyms

Name of Substance

  • Mometasone furoate
  • Mometasone furoate [USAN:USP:JAN]

MeSH Heading

  • Mometasone Furoate


  • 9,21-Dichloro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17-(2-furoate)
  • Asmanex
  • Asmanex Hfa
  • Asmanex Twisthaler
  • BRN 4340538
  • Danitin
  • Ecural
  • Elocon
  • Elocone
  • Elomet
  • Flumeta
  • LAS 41002
  • Mometasone furoate
  • Monovo
  • Nasonex
  • Nosorex
  • NSC 746171
  • NSC 760077
  • Ovixan
  • Propel
  • Rimelon
  • Sch 32088
  • Sinuva
  • UNII-04201GDN4R

Systematic Name

  • Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydroxy-16-methyl-, (11beta,16alpha)-

Mixture Name

  • Posatex

Registry Numbers

CAS Registry Number

  • 83919-23-7


  • 04201GDN4R

System Generated Number

  • 0083919237

Structure Descriptors








Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo subcutaneous 1gm/kg (1000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4203, 1990.
rat LD50 subcutaneous 300mg/kg (300mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4203, 1990.