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Substance Name: Bleomycin A6
RN: 37293-17-7
UNII: 0B19OCB220
InChIKey: FOUFFVYWFNBHHH-YNGSZULRSA-N

Notes

  • Forms conjugate with monoclonal antibody anti-CCT2 which binds to leukemia cells.
  • Forms conjugate with monoclonal antibody anti-CCT2 which binds to leukemia cells.

    NCI: Boanmycin hydrochloride. The hydrochloride salt form of boanmycin (aka bleomycin A6), a component of the antibiotic bleomycin produced by Streptomyces species, with potential antineoplastic activity. Upon administration, boanmycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals. This causes single- and double-stranded DNA breaks which eventually leads to cell death. Compared to bleomycin, boanmycin appears to have a more favorable toxicity profile. (NCI Thesaurus)

Molecular Formula

  • C60-H96-N20-O21-S2

Molecular Weight

  • 1497.6694
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Bleomycin A6

Synonyms

  • Bleomycin A6
  • Boanmycin
  • N(sup 1)-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)bleomycinamide
  • Pingyangmycin A6
  • UNII-0B19OCB220
  • Zhengguangmycin A6

Systematic Names

  • Bleomycinamide, N(sup 1)-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-
  • Bleomycinamide, N1-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-

Registry Numbers

CAS Registry Number

  • 37293-17-7

FDA UNII

  • 0B19OCB220

Other Registry Number

  • 11032-73-8

System Generated Number

  • 0037293177

Structure Descriptors

InChI

1S/C60H96N20O21S2/c1-25-38(77-51(80-49(25)64)30(17-36(63)84)72-18-29(62)50(65)90)55(94)79-40(46(31-19-69-24-73-31)99-59-48(44(88)42(86)34(20-81)98-59)100-58-45(89)47(101-60(66)96)43(87)35(21-82)97-58)56(95)74-27(3)41(85)26(2)52(91)78-39(28(4)83)54(93)71-16-9-37-75-33(23-102-37)57-76-32(22-103-57)53(92)70-15-8-14-68-12-6-5-11-67-13-7-10-61/h19,22-24,26-30,34-35,39-48,58-59,67-68,72,81-83,85-89H,5-18,20-21,61-62H2,1-4H3,(H2,63,84)(H2,65,90)(H2,66,96)(H,69,73)(H,70,92)(H,71,93)(H,74,95)(H,78,91)(H,79,94)(H2,64,77,80)/t26-,27+,28+,29-,30-,34-,35+,39-,40-,41-,42+,43+,44-,45-,46-,47-,48-,58+,59-/m0/s1

InChIKey

FOUFFVYWFNBHHH-YNGSZULRSA-N

Smiles

Cc1c(nc(nc1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@@H]([C@H](c2cnc[nH]2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCc5nc(cs5)c6nc(cs6)C(=O)NCCCNCCCCNCCCN)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 70530ug/kg (70.53mg/kg)   Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. Vol. 15, Pg. 453, 1990.
mouse LD50 intraperitoneal 102mg/kg (102mg/kg)   Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. Vol. 15, Pg. 453, 1990.
mouse LD50 intravenous 97780ug/kg (97.78mg/kg)   Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. Vol. 15, Pg. 453, 1990.
mouse LD50 subcutaneous 80330ug/kg (80.33mg/kg)   Zhongguo Kangshengsu Zazhi. Chinese Journal of Antibiotics. Vol. 15, Pg. 453, 1990.