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Substance Name: Goserelin [USAN:INN:BAN]
RN: 65807-02-5
UNII: 0F65R8P09N
InChIKey: BLCLNMBMMGCOAS-URPVMXJPSA-N

Note

  • A synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE. Goserelin is used in treatments of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer.

Molecular Formula

  • C59-H84-N18-O14

Molecular Weight

  • 1269.4246
 

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Drug / Therapeutic Agent
  • Human Data
  • LHRH Agonist
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Goserelin
  • Goserelin [USAN:INN:BAN]

MeSH Heading

  • Goserelin

Synonyms

  • 1-(5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-L-prolyl)semicarbazide
  • D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH
  • Decapeptide I
  • Goserelin
  • Goserelina
  • Goserelina [Spanish]
  • Gosereline
  • Gosereline [French]
  • Goserelinum
  • Goserelinum [Latin]
  • HSDB 7606
  • ICI 118,630
  • ICI 118630
  • UNII-0F65R8P09N
  • Zoladex

Systematic Name

  • Luteinizing hormone-releasing factor (pig), 6-(O-(1,1-dimethylethyl)-D-serine)-10-deglycinamide-, 2-(aminocarbonyl)hydrazide

Registry Numbers

CAS Registry Number

  • 65807-02-5

FDA UNII

  • 0F65R8P09N

Other Registry Number

  • 70280-59-0

System Generated Number

  • 0065807025

Structure Descriptors

InChI

InChI=1S/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90)/t38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1

InChIKey

BLCLNMBMMGCOAS-URPVMXJPSA-N

Smiles

CC(C)C[C@H](NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N6CCC[C@H]6C(=O)NNC(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo subcutaneous 51ug/kg (0.051mg/kg) BRAIN AND COVERINGS: "CHANGES IN CIRCULATION (HEMORRHAGE, THROMBOSIS, ETC.)"

SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE
Lancet. Vol. 345, Pg. 458, 1995.