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Substance Name: Indomethacin sodium [USAN:USP]
RN: 74252-25-8
UNII: 0IMX38M2GG
InChIKey: UHYAQBLOGVNWNT-UHFFFAOYSA-M

Classification Code

  • Anti-Inflammatory

Molecular Formula

  • C19-H15-Cl-N-Na-O4.3H2-O

Molecular Weight

  • 433.8179
 
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Names and Synonyms

Name of Substance

  • Indomethacin sodium [USAN:USP]

Synonyms

  • Indocin
  • Indocin I.V.
  • Indomethacin sodium
  • Indomethacin sodium trihydrate
  • Sodium 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate, trihydrate
  • UNII-0IMX38M2GG

Systematic Name

  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodium salt, trihydrate

Registry Numbers

CAS Registry Number

  • 74252-25-8

FDA UNII

  • 0IMX38M2GG

Related Registry Number

  • 53-86-1 (Parent)

System Generated Number

  • 0074252258

Molecular Formulas

Molecular Formula

  • C19-H15-Cl-N-Na-O4.3H2-O

Molecular Formula Fragments

  • C19-H15-Cl-N-Na-O4
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/C19H16ClNO4.Na.3H2O/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12;;;;/h3-9H,10H2,1-2H3,(H,22,23);;3*1H2/q;+1;;;/p-1

InChIKey

UHYAQBLOGVNWNT-UHFFFAOYSA-M

Smiles

Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)[O-].O.O.O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 unreported > 81mg/kg (81mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
mouse LD50 intravenous 23mg/kg (23mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: PERITONITIS		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
mouse LD50 oral 21mg/kg (21mg/kg) GASTROINTESTINAL: PERITONITIS

GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
mouse LD50 subcutaneous 21mg/kg (21mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: PERITONITIS

GASTROINTESTINAL: OTHER CHANGES		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
rat LD50 intravenous 23mg/kg (23mg/kg) GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: PERITONITIS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
rat LD50 oral 21mg/kg (21mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: PERITONITIS		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.
rat LD50 subcutaneous 21mg/kg (21mg/kg) GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: PERITONITIS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 952, 1995.