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Substance Name: Cyproheptadine hydrochloride anhydrous
RN: 969-33-5
UNII: 0S9323MCT0
InChIKey: ZPMVNZLARAEGHB-UHFFFAOYSA-N

Note

  • A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.

Molecular Formula

  • C21-H21-N.Cl-H

Molecular Weight

  • 323.8648
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Cyproheptadine hydrochloride anhydrous

Synonyms

  • 1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine hydrochloride
  • 4-(5-Dibenzo(a,e)cycloheptatrienylidene)piperidine hydrochloride
  • AI3-26940
  • Anarexol
  • Antegan
  • Cipractin
  • component of Dronactin
  • Contrallerg
  • Cyproheptadiene hydrochloride
  • Cyproheptadine chlorhydrate
  • Cyproheptadine HCl
  • Cyproheptadine hydrochloride
  • EINECS 213-535-1
  • Istam
  • Kulinet
  • Kyliver
  • NSC 169911
  • Nuran
  • Periactin
  • Periactin hydrochloride
  • Periactin syrup
  • Periactinol (VAN)
  • Periactinol hydrochloride
  • Peritol
  • Sialotin
  • UNII-0S9323MCT0
  • Vinorex
  • VUFB3511

Systematic Names

  • Cyproheptadine hydrochloride
  • Piperidine, 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 969-33-5

FDA UNII

  • 0S9323MCT0

System Generated Number

  • 0000969335

Molecular Formulas

Molecular Formula

  • C21-H21-N.Cl-H

Molecular Formula Fragments

  • C21-H21-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H21N.ClH/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;/h2-11H,12-15H2,1H3;1H

InChIKey

ZPMVNZLARAEGHB-UHFFFAOYSA-N

Smiles

CN1CCC(=C2c3ccccc3C=Cc4c2cccc4)CC1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 216mg/kg (216mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 4, Pg. 264, 1974.
mouse LD50 intraperitoneal 55300ug/kg (55.3mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 375, 1980.
mouse LD50 intravenous 23mg/kg (23mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 375, 1980.
mouse LD50 oral 69mg/kg (69mg/kg)   Agents and Actions, A Swiss Journal of Pharmacology. Vol. 4, Pg. 264, 1974.
mouse LD50 subcutaneous 107mg/kg (107mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 375, 1980.
rat LD50 intraperitoneal 52400ug/kg (52.4mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 375, 1980.
rat LD50 oral 295mg/kg (295mg/kg)   Drugs in Japan Vol. 6, Pg. 340, 1982.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 375, 1980.
women TDLo oral 7mg/kg/4W-C (7mg/kg) LIVER: "JAUNDICE, CHOLESTATIC"

GASTROINTESTINAL: OTHER CHANGES

LIVER: LIVER FUNCTION TESTS IMPAIRED
British Medical Journal. Vol. 1, Pg. 753, 1978.