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Substance Name: Tribromoethanol [NF]
RN: 75-80-9
UNII: 149JI83A44
InChIKey: YFDSDPIBEUFTMI-UHFFFAOYSA-N

Classification Codes

  • Anesthetics
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C2-H3-Br3-O

Molecular Weight

  • 282.757
 
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Names and Synonyms

Name of Substance

  • Tribromoethanol [NF]

Synonyms

  • 2,2,2-Tribromoethanol
  • 2,2,2-Tribromoethyl alcohol
  • 3-01-00-01362 (Beilstein Handbook Reference)
  • Avertin
  • Avertine
  • Basibrol
  • BRN 1733249
  • Bromethol
  • EINECS 200-903-1
  • Ethobrom
  • Ethobrome
  • Narcolan
  • Narcotyl
  • Narkolan
  • NSC 2189
  • Rectanol
  • Tribromethanol
  • Tribromoethanol
  • Tribromoethanol (VAN)
  • Tribromoethyl alcohol
  • UNII-149JI83A44

Systematic Names

  • 2,2,2-Tribromoethanol
  • Ethanol, 2,2,2-tribromo-

Registry Numbers

CAS Registry Number

  • 75-80-9

FDA UNII

  • 149JI83A44

Other Registry Number

  • 8002-84-4

System Generated Number

  • 0000075809

Structure Descriptors

InChI

InChI=1S/C2H3Br3O/c3-2(4,5)1-6/h6H,1H2

InChIKey

YFDSDPIBEUFTMI-UHFFFAOYSA-N

Smiles

OCC(Br)(Br)Br

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 930mg/kg (930mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal of Pharmaceutical Sciences. Vol. 56, Pg. 920, 1967.
rabbit LDLo intraperitoneal 450mg/kg (450mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: GENERAL ANESTHETIC
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 132, Pg. 214, 1928.
rabbit LDLo oral 1100mg/kg (1100mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: GENERAL ANESTHETIC
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 132, Pg. 214, 1928.
rabbit LDLo rectal 300mg/kg (300mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 55, Pg. 1, 1935.
rat LDLo intraperitoneal 300mg/kg (300mg/kg)   Laboratory Animal Science. Vol. 49, Pg. 665, 1999.
rat LDLo intraperitoneal 300mg/kg (300mg/kg) LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"

GASTROINTESTINAL: OTHER CHANGES
Laboratory Animal Science. Vol. 49, Pg. 665, 1999.
rat LDLo oral 1gm/kg (1000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 63, Pg. 183, 1938.
rat LDLo subcutaneous 530mg/kg (530mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 182, Pg. 348, 1936.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 81 deg C   EXP
log P (octanol-water) 2.1 (none)   EXP
Water Solubility 3.40E+04 mg/L 40 EXP
Vapor Pressure 1.72E-03 mm Hg 25 EST
Henry's Law Constant 5.47E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.69E-13 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.