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Substance Name: Aminooxyacetic acid
RN: 645-88-5
UNII: 14I68GI3OQ
InChIKey: NQRKYASMKDDGHT-UHFFFAOYSA-N
Note
- A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.
Molecular Formula
- C2-H5-N-O3
Molecular Weight
- 91.0655
Classification Codes
- Enzyme Inhibitors
- GABA Agents
- Mutation Data
- Neurotransmitter Agents
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Names and Synonyms
Name of Substance
- Aminooxyacetic acid
MeSH Heading
- Aminooxyacetic acid
Synonyms
- (Carboxymethoxy)amine
- (o-Carboxymethyl)hydroxylamine
- 4-03-00-00577 (Beilstein Handbook Reference)
- Aminooxyacetic acid
- AOAA
- BRN 0878238
- U 7524
- UNII-14I68GI3OQ
Systematic Name
- Acetic acid, (aminooxy)-
Registry Numbers
CAS Registry Number
- 645-88-5
FDA UNII
- 14I68GI3OQ
System Generated Number
- 0000645885
Structure Descriptors
InChI
InChI=1S/C2H5NO3/c3-6-1-2(4)5/h1,3H2,(H,4,5)InChIKey
NQRKYASMKDDGHT-UHFFFAOYSA-NSmiles
NOCC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 40mg/kg (40mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Biochemical Pharmacology. Vol. 28, Pg. 1397, 1979. |
| mouse | LD50 | subcutaneous | 40mg/kg (40mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Biochemical Pharmacology. Vol. 27, Pg. 103, 1978. |
| mouse | LD50 | unreported | 342mg/kg (342mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62(1), Pg. 20S, 1966. | |
| rat | LD50 | intraperitoneal | 145mg/kg (145mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62(2), Pg. 95S, 1966. |
| rat | LD50 | unreported | 145mg/kg (145mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62(1), Pg. 20S, 1966. |