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Substance Name: Aminooxyacetic acid
RN: 645-88-5
UNII: 14I68GI3OQ
InChIKey: NQRKYASMKDDGHT-UHFFFAOYSA-N

Note

  • A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.

Molecular Formula

  • C2-H5-N-O3

Molecular Weight

  • 91.0655
 

Classification Codes

  • Enzyme Inhibitors
  • GABA Agents
  • Mutation Data
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • Aminooxyacetic acid

MeSH Heading

  • Aminooxyacetic acid

Synonyms

  • (Carboxymethoxy)amine
  • (o-Carboxymethyl)hydroxylamine
  • 4-03-00-00577 (Beilstein Handbook Reference)
  • Aminooxyacetic acid
  • AOAA
  • BRN 0878238
  • U 7524
  • UNII-14I68GI3OQ

Systematic Name

  • Acetic acid, (aminooxy)-

Registry Numbers

CAS Registry Number

  • 645-88-5

FDA UNII

  • 14I68GI3OQ

System Generated Number

  • 0000645885

Structure Descriptors

InChI

InChI=1S/C2H5NO3/c3-6-1-2(4)5/h1,3H2,(H,4,5)

InChIKey

NQRKYASMKDDGHT-UHFFFAOYSA-N

Smiles

NOCC(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 40mg/kg (40mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Biochemical Pharmacology. Vol. 28, Pg. 1397, 1979.
mouse LD50 subcutaneous 40mg/kg (40mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Biochemical Pharmacology. Vol. 27, Pg. 103, 1978.
mouse LD50 unreported 342mg/kg (342mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62(1), Pg. 20S, 1966.
rat LD50 intraperitoneal 145mg/kg (145mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62(2), Pg. 95S, 1966.
rat LD50 unreported 145mg/kg (145mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62(1), Pg. 20S, 1966.