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Substance Name: Perindopril erbumine [USAN]
RN: 107133-36-8
UNII: 1964X464OJ
InChIKey: IYNMDWMQHSMDDE-MHXJNQAMSA-N
Note
- An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.
Molecular Formula
- C19-H32-N2-O5.C4-H11-N
Molecular Weight
- 441.6087
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive
- Antihypertensive Agents
- Cardiovascular Agents
- Enzyme Inhibitor (Angiotensin-Converting)
- Protease Inhibitors
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Names and Synonyms
Name of Substance
- Perindopril erbumine [USAN]
MeSH Heading
- Perindopril
Synonyms
- (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester, compound with tert-butylamine (1:1)
- ACEON
- Covapril
- McN-A-2833-109
- Perindopril erbumine
- Perindopril tert-butylamine
- S-9490-3
- UNII-1964X464OJ
Systematic Name
- 1H-Indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,7abeta))-, compd. with 2-methyl-2-propanamine (1:1)
Registry Numbers
CAS Registry Number
- 107133-36-8
FDA UNII
- 1964X464OJ
System Generated Number
- 0107133368
Molecular Formulas
Molecular Formula
- C19-H32-N2-O5.C4-H11-N
Molecular Formula Fragments
- C19-H32-N2-O5
- C4-H11-N
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C19H32N2O5.C4H11N/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24;1-4(2,3)5/h12-16,20H,4-11H2,1-3H3,(H,23,24);5H2,1-3H3/t12-,13-,14-,15-,16-;/m0./s1InChIKey
IYNMDWMQHSMDDE-MHXJNQAMSA-NSmiles
CCC[C@H](N[C@@H](C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD | oral | > 2500mg/kg (2500mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 3147, 1998. | |
mouse | LD50 | intravenous | 323mg/kg (323mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 3147, 1998. | |
rat | LD | oral | > 2500mg/kg (2500mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 3147, 1998. | |
rat | LD50 | intravenous | 323mg/kg (323mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 3147, 1998. |