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Substance Name: Perindopril erbumine [USAN]
RN: 107133-36-8
UNII: 1964X464OJ
InChIKey: IYNMDWMQHSMDDE-MHXJNQAMSA-N

Note

  • An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.

Molecular Formula

  • C19-H32-N2-O5.C4-H11-N

Molecular Weight

  • 441.6087
 

Classification Codes

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Enzyme Inhibitor (Angiotensin-Converting)
  • Protease Inhibitors

Names and Synonyms

Name of Substance

  • Perindopril erbumine [USAN]

MeSH Heading

  • Perindopril

Synonyms

  • (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester, compound with tert-butylamine (1:1)
  • ACEON
  • Covapril
  • McN-A-2833-109
  • Perindopril erbumine
  • Perindopril tert-butylamine
  • S-9490-3
  • UNII-1964X464OJ

Systematic Name

  • 1H-Indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,7abeta))-, compd. with 2-methyl-2-propanamine (1:1)

Registry Numbers

CAS Registry Number

  • 107133-36-8

FDA UNII

  • 1964X464OJ

System Generated Number

  • 0107133368

Molecular Formulas

Molecular Formula

  • C19-H32-N2-O5.C4-H11-N

Molecular Formula Fragments

  • C19-H32-N2-O5
  • C4-H11-N
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C19H32N2O5.C4H11N/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24;1-4(2,3)5/h12-16,20H,4-11H2,1-3H3,(H,23,24);5H2,1-3H3/t12-,13-,14-,15-,16-;/m0./s1

InChIKey

IYNMDWMQHSMDDE-MHXJNQAMSA-N

Smiles

CCC[C@H](N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O)C(=O)OCC.CC(C)(C)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 2500mg/kg (2500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 3147, 1998.
mouse LD50 intravenous 323mg/kg (323mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 3147, 1998.
rat LD oral > 2500mg/kg (2500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 3147, 1998.
rat LD50 intravenous 323mg/kg (323mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 3147, 1998.