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Substance Name: Cabozantinib [USAN:INN]
RN: 849217-68-1
UNII: 1C39JW444G
InChIKey: ONIQOQHATWINJY-UHFFFAOYSA-N
Notes
- A multikinase inhibitor.
- A multikinase inhibitor.
NCI: An orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several tyrosine receptor kinases. Specifically, cabozantinib appears to have a strong affinity for the hepatocyte growth factor receptor (Met) and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in inhibition of tumor growth and angiogenesis, and tumor regression. This agent has also been shown to inhibit mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (Flt3) and tyrosine-protein kinase receptor (Tie-2). (NCI Thesaurus)
Molecular Formula
- C28-H24-F-N3-O5
Molecular Weight
- 501.5116
Classification Code
- Antineoplastic
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Names and Synonyms
Name of Substance
- Cabozantinib
- Cabozantinib [USAN:INN]
Synonyms
- BMS 907351
- BMS-907351
- Cabozantinib
- Cometriq
- UNII-1C39JW444G
- XL 184
- XL-184
- XL184
- XL184 cpd
Systematic Name
- 1,1-Cyclopropanedicarboxamide, N'-(4-((6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4- fluorophenyl)-
Registry Numbers
CAS Registry Number
- 849217-68-1
FDA UNII
- 1C39JW444G
System Generated Number
- 0849217681