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Substance Name: Onercept [USAN:INN]
RN: 199685-57-9
UNII: 1IEO802L3J

Note

  • A recombinant human soluble p55 tumor necrosis factor binding protein for the treatment of a number of disorders, including Crohn's disease, psoriasis and psoriatic arthritis; TNFbp (pharmacologic) is the dimeric polyethylene glycol linked form of the type I soluble receptor of tumor necrosis factor (TNF) that acts as a TNF inhibitor.

Molecular Formula

  • C753-H1156-N228-O247-S25

Molecular Weight

  • 18156.4144
 

Classification Codes

  • Anti-TNF (Tumor Necrosis Factor) Activity
  • TNF Binding Proteins
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Names and Synonyms

Name of Substance

  • Onercept [USAN:INN]

Synonyms

  • Glycoprotein TNF-BP (tumor necrosis factor-binding protein) (human disulfide variant 1). Molecular weight is approximately 18,000 daltons
  • Glycoprotein TNF-BP (tumor necrosis factor-binding protein) (human disulfide varinat 1)
  • Human soluble TNF p55 receptor
  • Onercept
  • r-hTBP-1
  • Recombinant human soluble p55 tumor necrosis factor binding protein
  • Recombinant human soluble p55 tumour necrosis factor receptor
  • UNII-1IEO802L3J

Registry Numbers

CAS Registry Number

  • 199685-57-9

FDA UNII

  • 1IEO802L3J

System Generated Number

  • 0199685579

Structure Descriptors

Smiles

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]5CSSC[C@@H]6NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc7cnc[nH]7)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC6=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N5)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](Cc8ccccc8)NC(=O)[C@@H]9CSSC[C@H](NC(=O)CNC(=O)[C@@H]%10CSSC[C@@H]%11NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC%11=O)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N%10)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]%12CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]%13CSSC[C@@H]%14NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](Cc%15ccc(O)cc%15)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc%16ccc(O)cc%16)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc%17cnc[nH]%17)NC%14=O)[C@@H](C)O)C(=O)N%18CCC[C@H]%18C(=O)NCC(=O)N%19CCC[C@H]%19C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N%13)NC(=O)[C@@H]%20CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N%21CCC[C@H]%21C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc%22ccc(O)cc%22)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc%23cnc[nH]%23)C(=O)N%24CCC[C@H]%24C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N%20)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc%25ccccc%25)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc%26cnc[nH]%26)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc%27cnc[nH]%27)C(=O)N%12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc%28ccc(O)cc%28)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc%29cnc[nH]%29)C(=O)N[C@@H](Cc%30ccc(O)cc%30)C(=O)N[C@@H](Cc%31c[nH]c%32ccccc%31%32)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc%33ccccc%33)C(=O)N[C@@H](CCC(=O)N)C(=O)N9)[C@@H](C)O)C(=O)N[C@@H](Cc%34cnc[nH]%34)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc%35ccccc%35)C(=O)N[C@@H](Cc%36ccccc%36)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N4)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)O