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Substance Name: p-Cresol
RN: 106-44-5
UNII: 1MXY2UM8NV
InChIKey: IWDCLRJOBJJRNH-UHFFFAOYSA-N

Note

  • Chemical remains on MTL because of additional testing actions (see Hazardous Air Pollutants Category listing)

Molecular Formula

  • C7-H8-O

Molecular Weight

  • 108.1392
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 170
  • 2011 CERCLA Priority List, Rank: 172
  • Reportable Quantity (RQ) = 100 lb
  • TWA (2 ppm); Skin; BEI
  • TWA 5 mg/m3 (22 ppm); skin;

Names and Synonyms

Name of Substance

  • 4-Cresol
  • 4-Methylphenol
  • p-Cresol
  • Para-cresol
  • Phenol, 4-methyl-

Synonyms

  • 1-Hydroxy-4-methylbenzene
  • 1-Methyl-4-hydroxybenzene
  • 4-Cresol
  • 4-Hydroxytoluene
  • 4-Methylphenol
  • AI3-00150
  • CCRIS 647
  • EC 203-398-6
  • EINECS 203-398-6
  • FEMA No. 2337
  • FEMA Number 2337
  • HSDB 1814
  • NSC 3696
  • p-Cresol
  • p-Cresylic acid
  • p-Hydroxytoluene
  • p-Kresol
  • p-Kresol [German]
  • p-Methylhydroxybenzene
  • p-Methylphenol
  • p-Oxytoluene
  • p-Toluol
  • p-Tolyl alcohol
  • Para-cresol
  • para-Cresylic acid
  • Paramethyl phenol
  • Phenol, 4-methyl-
  • RCRA waste number U052
  • UNII-1MXY2UM8NV

Systematic Names

  • p-Cresol
  • Phenol, 4-methyl-

Superlist Names

  • 4-Methylphenol
  • Cresol, all isomers
  • Cresol, p-
  • Cresol, p-isomer
  • Cresol, para-
  • p-Cresol
  • p-Cresol [UN2076] [Poison, Corrosive]
  • p-Cresylic acid
  • UN2076

Registry Numbers

CAS Registry Number

  • 106-44-5

FDA UNII

  • 1MXY2UM8NV

Related Registry Numbers

  • 1121-70-6 (hydrochloride salt)
  • 72269-62-6 (aluminum salt)

System Generated Number

  • 0000106445

Structure Descriptors

InChI

InChI=1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3

InChIKey

IWDCLRJOBJJRNH-UHFFFAOYSA-N

Smiles

Cc1ccc(O)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 80mg/kg (80mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.
frog LDLo subcutaneous 150mg/kg (150mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.
guinea pig LDLo subcutaneous 200mg/kg (200mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 58, 1959.
mouse LD50 intraperitoneal 25mg/kg (25mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 58, 1959.
mouse LD50 oral 344mg/kg (344mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.
mouse LD50 unreported 160mg/kg (160mg/kg)   British Journal of Cancer. Vol. 6, Pg. 160, 1952.
mouse LDLo subcutaneous 150mg/kg (150mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.
rabbit LD50 skin 301mg/kg (301mg/kg) BEHAVIORAL: TREMOR

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 5-5/1969,
rabbit LDLo intravenous 180mg/kg (180mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.
rabbit LDLo oral 620mg/kg (620mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.
rabbit LDLo subcutaneous 300mg/kg (300mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.
rat LC50 inhalation > 710mg/m3/1H (710mg/m3)   BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 5-5/1969,
rat LD50 oral 207mg/kg (207mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION		 BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 5-5/1969,
rat LD50 skin 750mg/kg (750mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.
rat LD50 unreported 1440mg/kg (1440mg/kg)   Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. Vol. 8, Pg. 145, 1972.
rat LDLo subcutaneous 500mg/kg (500mg/kg)   "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 58, 1959.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 35.5 deg C   EXP
Boiling Point 201.9 deg C   EXP
pKa Dissociation Constant 10.26 (none) 25 EXP
log P (octanol-water) 1.94 (none)   EXP
Water Solubility 2.15E+04 mg/L 25 EXP
Vapor Pressure 0.11 mm Hg 25 EXP
Henry's Law Constant 1.00E-06 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 4.70E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.