Skip Navigation
ChemIDplus LiteBrowseAdvanced

Substance Name: Tolvaptan [USAN:INN:BAN]
RN: 150683-30-0
UNII: 21G72T1950
InChIKey: GYHCTFXIZSNGJT-UHFFFAOYSA-N

Notes

  • A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency.
  • DailyMed: Tolvaptan is a selective vasopressin V2-receptor antagonist with an affinity for the V2-receptor that is 1.8 times that of native arginine vasopressin (AVP).

Molecular Formula

  • C26-H25-Cl-N2-O3

Molecular Weight

  • 448.9475
 

Classification Codes

  • Antidiuretic Hormone Receptor Antagonists
  • Natriuretic Agents
  • Treatment of Congestive Heart Failure and Hyponatremia (Vasopressin V2 Receptor Antagonist)
  • Vasopressin V2 Receptor Antagonist
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Tolvaptan
  • Tolvaptan [USAN:INN:BAN]

MeSH Heading

  • Tolvaptan

Synonyms

  • (+-)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl) carbonyl)-o-tolu-m-toluidide
  • 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
  • Benzamide, N-(4-((7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-3-methylphenyl)-2-methyl-
  • HSDB 8196
  • OPC 41061
  • OPC-41061
  • Samsca
  • Tolvaptan
  • UNII-21G72T1950

Systematic Name

  • (+-)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-o-tolu-m-toluidide

Registry Numbers

CAS Registry Number

  • 150683-30-0

FDA UNII

  • 21G72T1950

System Generated Number

  • 0150683300

Structure Descriptors

InChI

InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)

InChIKey

GYHCTFXIZSNGJT-UHFFFAOYSA-N

Smiles

Cc1ccccc1C(=O)Nc2ccc(C(=O)N3CCCC(O)c4cc(Cl)ccc34)c(C)c2