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Substance Name: Penitrem A
RN: 12627-35-9
UNII: 244AU85PR7
InChIKey: JDUWHZOLEDOQSR-JKPSMKLGSA-N

Note

  • Tremorigenic toxin from Penicillium palitans & P.crustosum.

Classification Codes

  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C37-H44-Cl-N-O6

Molecular Weight

  • 634.2086
 
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Names and Synonyms

Name of Substance

  • Penitrem A

Synonyms

  • NSC 354845
  • Penitrem A
  • Tremortin A
  • UNII-244AU85PR7

Systematic Name

  • Penitrem A

Registry Numbers

CAS Registry Number

  • 12627-35-9

FDA UNII

  • 244AU85PR7

Other Registry Number

  • 12679-82-2

System Generated Number

  • 0012627359

Structure Descriptors

InChI

InChI=1S/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,28+,29-,31+,33+,34+,35-,36+,37-/m0/s1

InChIKey

JDUWHZOLEDOQSR-JKPSMKLGSA-N

Smiles

CC(=C)[C@H]1O[C@H]2CC[C@]3(C)[C@]4(C)[C@@H](CC[C@@]3(O)[C@]25O[C@@H]5[C@H]1O)[C@@H]6OC(C)(C)[C@H]7C[C@@H]8C(=C)Cc9c(Cl)cc%10[nH]c4c6c%10c9[C@]78O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 42mg/kg (42mg/kg)   Veterinary and Human Toxicology. Vol. 32(Suppl), Pg. 63, 1990.
dog LDLo intraperitoneal 500ug/kg (0.5mg/kg) BEHAVIORAL: TETANY

LIVER: FATTY LIVER DEGERATION
Toxicology and Applied Pharmacology. Vol. 35, Pg. 311, 1976.
mouse LD50 oral 10mg/kg (10mg/kg)   "Toxicology, Biochemistry and Pathology of Mycotoxins," Uraguchi, K. and M. Yamazaki, eds., New York, John Wiley & Sons, Inc., 1978Vol. -, Pg. 108, 1978.
mouse LDLo intraperitoneal 1100ug/kg (1.1mg/kg)   Clinical Toxicology. Vol. 17, Pg. 45, 1980.