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Substance Name: Spirogermanium hydrochloride [USAN]
RN: 41992-22-7
UNII: 25S5I1P6O6
InChIKey: GRLUHXSUZYFZCW-UHFFFAOYSA-N

Classification Codes

  • Antineoplastic
  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H36-Ge-N2.2Cl-H

Molecular Weight

  • 414.017
 
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Names and Synonyms

Name of Substance

  • Spirogermanium dihydrochloride
  • Spirogermanium hydrochloride [USAN]

Synonyms

  • 2-(3-(Dimethylamino)propyl)-8,8-diethyl-2-aza-8-germaspiro(4.5)decane dihydrochloride
  • 2-Aza-8-germaspiro(4.5)decane-2-propanamine, 8,8-diethyl-N,N-dimethyl-, dihydrochloride
  • 8,8-Diethyl-N,N-dimethyl-2-aza-8-germaspiro(4.5)decane-2-propanamine dihydrochloride
  • NSC 192965
  • S 99 A
  • Spiro-32
  • Spirogermanium dihydrochloride
  • Spirogermanium HCl
  • Spirogermanium hydrochloride
  • UNII-25S5I1P6O6

Systematic Name

  • 2-Aza-8-germaspiro(4.5)decane-2-propanamine, 8,8-diethyl-N,N-dimethyl-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 41992-22-7

FDA UNII

  • 25S5I1P6O6

Related Registry Number

  • 41992-23-8 (Parent)

System Generated Number

  • 0041992227

Molecular Formulas

Molecular Formula

  • C17-H36-Ge-N2.2Cl-H

Molecular Formula Fragments

  • C17-H36-Ge-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H36GeN2.2ClH/c1-5-18(6-2)11-8-17(9-12-18)10-15-20(16-17)14-7-13-19(3)4;;/h5-16H2,1-4H3;2*1H

InChIKey

GRLUHXSUZYFZCW-UHFFFAOYSA-N

Smiles

C12(C[N@@](CCCN(C)C)CC2)CC[Ge](CC)(CC)CC1.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intramuscular 40mg/kg (40mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Cancer Treatment Reports. Vol. 64, Pg. 1207, 1980.
dog LDLo intravenous 40mg/kg (40mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Cancer Treatment Reports. Vol. 64, Pg. 1207, 1980.
mouse LD50 intramuscular 119mg/kg (119mg/kg) BLOOD: HEMORRHAGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: OTHER CHANGES
Cancer Treatment Reports. Vol. 64, Pg. 1207, 1980.
mouse LD50 intravenous 41500ug/kg (41.5mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
National Technical Information Service. Vol. PB264-117,
rat LD50 intraperitoneal 107mg/kg (107mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat LD50 subcutaneous 210mg/kg (210mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,