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Substance Name: Vismodegib [USAN:INN]
RN: 879085-55-9
UNII: 25X868M3DS
InChIKey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Note
- Inhibits the hedgehog pathway and ABC transporters; has antineoplastic activity.
NCI: An orally bioavailable small molecule with potential antineoplastic activity. Vismodegib targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO. (NCI Thesaurus)
Molecular Formula
- C19-H14-Cl2-N2-O3-S
Molecular Weight
- 421.3026
Classification Codes
- Antineoplastic
- Antineoplastic Agents
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Names and Synonyms
Name of Substance
- HhAntag691
- Vismodegib [USAN:INN]
Synonyms
- Erivedge
- GDC 0449
- GDC-0449
- GDC0449
- HSDB 8130
- NSC 747691
- R 3616
- UNII-25X868M3DS
- Vismodegib
Systematic Name
- Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-
Registry Numbers
CAS Registry Number
- 879085-55-9
FDA UNII
- 25X868M3DS
System Generated Number
- 0879085559