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Substance Name: Cefadroxil [USAN:USP:INN:BAN:JAN]
RN: 66592-87-8
UNII: 280111G160
InChIKey: NBFNMSULHIODTC-CYJZLJNKSA-N

Note

  • Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.

Molecular Formula

  • C16-H17-N3-O5-S.H2-O

Molecular Weight

  • 381.4071
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Cefadroxil [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Cefadroxil

Synonyms

  • (6R,7R)-7-((R)-2-Amino-2-(p-hydroxyphenyl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monohydrate
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-, monohydrate, (6R-(6alpha,7beta(R*)))-
  • Baxan Kapseln
  • Bidocel
  • BL-S 578
  • BL-S578
  • Cefadroxil
  • Cefadroxil 1-wasser
  • Cefadroxil monohydrate
  • Cefos Granulat
  • Duricef
  • Kefroxil Kapseln
  • MJF 11567-3
  • Moxacef Kapseln
  • Omnidrox Kapseln
  • Ultracef
  • UNII-280111G160

Systematic Names

  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-, monohydrate, (6R,7R)-
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-, monohydrate, (6R-(6alpha,7beta(R*)))-

Registry Numbers

CAS Registry Number

  • 66592-87-8

FDA UNII

  • 280111G160

System Generated Number

  • 0066592878

Molecular Formulas

Molecular Formula

  • C16-H17-N3-O5-S.H2-O

Molecular Formula Fragments

  • C16-H17-N3-O5-S
  • H2-O

Structure Descriptors

InChI

1S/C16H17N3O5S.H2O/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8;/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24);1H2/t10-,11-,15-;/m1./s1

InChIKey

NBFNMSULHIODTC-CYJZLJNKSA-N

Smiles

c1(ccc(O)cc1)[C@H](C(N[C@H]1[C@@H]2N(C(=C(C)CS2)C(O)=O)C1=O)=O)N.O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 6gm/kg (6000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.
mouse LD50 subcutaneous > 8gm/kg (8000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.
rat LD50 intraperitoneal > 6gm/kg (6000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.
rat LD50 oral > 10gm/kg (10000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.
rat LD50 subcutaneous > 8gm/kg (8000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.