Substance Name: Durvalumab [USAN:INN]
RN: 1428935-60-7
UNII: 28X28X9OKV
Notes
- An IgG1 that targets programmed cell death 1 ligand 1 (PD-L1); enhances the immune response to tumor cells and is used for the treatment of locally advanced or metastatic urothelial carcinoma.
- NCI: A Fc optimized monoclonal antibody directed against programmed cell death-1 ligand 1 (PD-L1; B7 homolog 1; B7H1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration, durvalumab binds to PD-L1, thereby blocking its binding to and activation of its receptor programmed death 1 (PD-1) expressed on activated T-cells. This may reverse T-cell inactivation and activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against PD-L1-expressing tumor cells. PD-L1, a member of the B7 protein superfamily, is overexpressed on certain tumor cell types and on various tumor-infiltrating immune cells. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in increased immune evasion. The Fc region of durvalumab is modified in such a way that it does not induce either antibody-dependent cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). (NCI Thesaurus)
Molecular Formula
- Unspecified
Classification Codes
- Antineoplastic Agents
- Antineoplastic Agents, Immunological
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Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Durvalumab [USAN:INN]
- MEDI-4736
Synonyms
- Durvalumab
- Imfinzi
- Immunoglobulin G1, anti-(human cd antigen cd274) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer
- Immunoglobulin G1, anti-(human protein B7-H1) (human monoclonal MEDI4736 heavy chain), disulfide with human monoclonal MEDI4736 kappa-chain, dimer
- MEDI 4736
- MEDI4736
- UNII-28X28X9OKV
Registry Numbers
CAS Registry Number
- 1428935-60-7
FDA UNII
- 28X28X9OKV
Other Registry Number
- 1493766-03-2
System Generated Number
- 1428935607