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Substance Name: Fenfluramine [INN:BAN]
RN: 458-24-2
UNII: 2DS058H2CF
InChIKey: DBGIVFWFUFKIQN-UHFFFAOYSA-N
Note
- A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
Molecular Formula
- C12-H16-F3-N
Molecular Weight
- 231.2594
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Drug / Therapeutic Agent
- Human Data
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Reproductive Effect
- Serotonin Agents
- Serotonin Uptake Inhibitors
Superlist Classification Code
- DEA Schedule IV
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Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Fenfluramine
- Fenfluramine [INN:BAN]
MeSH Heading
- Fenfluramine
Synonyms
- (+-)-Fenfluramine
- 1-(meta-Trifluoromethyl-phenyl)-2 ethylaminopropane
- 2-Ethylamino-1-(3-trifluoromethylphenyl)propane
- 3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
- Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-
- BRN 4783711
- dl-Fenfluramine
- DL-Fenfluramine
- EINECS 207-276-3
- Fenfluramina
- Fenfluramina [DCIT]
- Fenfluramine
- Fenfluraminum
- Fenfluraminum [INN-Latin]
- HSDB 3080
- N-Ethyl-alpha-methyl-3-(trifluoromethyl)benzeneethanamine
- N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine
- N-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine
- Obedrex
- Pesos
- Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-
- Ponderax PA
- Rotondin
- S 768
- UNII-2DS058H2CF
Systematic Names
- Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-
- Fenfluramine
- Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-
Superlist Names
- DEA No. 1670
- Fenfluramine
Registry Numbers
CAS Registry Number
- 458-24-2
FDA UNII
- 2DS058H2CF
Other Registry Numbers
- 25990-46-9
- 5220-89-3
Related Registry Number
- 404-82-0 (hydrochloride)
System Generated Number
- 0000458242
Structure Descriptors
InChI
InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3InChIKey
DBGIVFWFUFKIQN-UHFFFAOYSA-NSmiles
CCNC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | oral | 60mg/kg (60mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: REGIDITY SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970Vol. -, Pg. 75, 1970. |
dog | LD50 | oral | 100mg/kg (100mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: REGIDITY SKIN AND APPENDAGES (SKIN): HAIR: OTHER | "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970Vol. -, Pg. 75, 1970. |
human | LDLo | oral | 50mg/kg (50mg/kg) | CARDIAC: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Lancet. Vol. 2, Pg. 1306, 1969. |
man | TDLo | oral | 4286ug/kg (4.286mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC | Therapie. Vol. 34, Pg. 205, 1979. |
mouse | LD50 | intraperitoneal | 53mg/kg (53mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: REGIDITY | "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970Vol. -, Pg. 75, 1970. |
mouse | LD50 | oral | 145mg/kg (145mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 188, Pg. 271, 1970. | |
rabbit | LD50 | oral | 50mg/kg (50mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: REGIDITY SKIN AND APPENDAGES (SKIN): HAIR: OTHER | "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970Vol. -, Pg. 75, 1970. |
rat | LD50 | oral | 130mg/kg (130mg/kg) | Journal of Medicinal Chemistry. Vol. 18, Pg. 177, 1975. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 3.36 | (none) | EXP | |
Water Solubility | 412 | mg/L | 25 | EST |
Vapor Pressure | 0.041 | mm Hg | 25 | EST |
Henry's Law Constant | 2.73E-05 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 3.31E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.